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Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
05:51

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness

Published on: May 3, 2018

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Family patterns of arterial stiffness across three generations in the Malmö Offspring Study

Erik P Rosberg1, Peter M Nilsson

  • 1Department of Clinical Sciences, Lund University, Skane University Hospital, Malmo, Sweden.

Journal of Hypertension
|November 15, 2019
PubMed

Insights

Central haemodynamics, measured by carotid-femoral pulse wave velocity (c-f PWV), show a positive correlation across three generations. This suggests inherited patterns of arterial stiffness, impacting cardiovascular health.

Area of Science:

  • Cardiovascular Health
  • Genetics and Aging
  • Vascular Biology

Background:

  • Central haemodynamics are key predictors of cardiovascular health and disease risk.
  • Vascular aging and target organ damage are influenced by early changes in central haemodynamics.
  • Carotid-femoral pulse wave velocity (c-f PWV), augmentation index (Aix), and central SBP (cSBP) are key indicators of arterial stiffness.

Purpose of the Study:

  • To investigate the association between central haemodynamic patterns across three generations.
  • Focus on carotid-femoral pulse wave velocity (c-f PWV) as a measure of arterial stiffness.

Main Methods:

  • Included 1131 participants from the Malmö Diet Cancer Study (MDCS) and Malmö Offspring Study (MOS).
  • Measured c-f PWV in grandparents and offspring using Sphygmocor.
  • Conducted correlation analyses between offspring, parents, and grandparents' c-f PWV, with adjustments for age, sex, BMI, SBP, and fasting glucose.

Main Results:

  • A significant positive correlation was found between offspring c-f PWV and parents' c-f PWV (r=0.26, P<0.001).
  • Offspring c-f PWV also correlated positively with grandparents' c-f PWV (r=0.29, P<0.001).
  • Offspring of parents with high c-f PWV exhibited significantly higher mean c-f PWV.

Conclusions:

  • Carotid-femoral pulse wave velocity (c-f PWV), a measure of aortic stiffness, is positively correlated across three related generations.
  • Findings suggest a potential inherited component in arterial stiffness and its impact on cardiovascular health.
Abstract

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