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Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
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Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Implantation and Evaluation of Melanoma in the Murine Choroid via Optical Coherence Tomography

Published on: December 2, 2022

Histiocytoid Melanoma.

Nathan T Harvey^1,2, Jagbir Grewal¹, Nima Mesbah Ardakani¹

¹Department of Anatomical Pathology, PathWest Laboratory Medicine, Perth, Western Australia.

The American Journal of Dermatopathology

|November 15, 2019

Summary

Histiocytoid melanoma is a rare variant that mimics benign cells, posing diagnostic challenges. Early recognition and immunohistochemistry are crucial for adequate treatment and preventing recurrence.

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Area of Science:

Dermatopathology
Oncology

Background:

Melanoma diagnosis typically relies on characteristic microscopic features.
Unusual melanoma variants can mimic benign conditions, complicating diagnosis.

Observation:

Five cases of a subtle melanoma variant, termed "histiocytoid melanoma," are presented.
Clinically, these lesions appear as ill-defined pigmented areas, sometimes extensive.
Microscopically, they exhibit interstitial infiltration by single cells with histiocytoid morphology resembling melanophages.

Findings:

Immunohistochemistry confirmed melanoma, with positive Sox-10 and Melan-A labeling.
Surgical margins were often involved, requiring re-excision.
Locoregional recurrence was common, but no distant metastases or melanoma-related deaths occurred.

Implications:

Histiocytoid melanoma requires recognition due to its subtle appearance and potential for incomplete excision.
Accurate histological clearance is essential for managing this uncommon melanoma subtype.
Understanding this variant aids in appropriate patient management and prognosis assessment.