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Humanized NOD/SCID/IL2rγnull (hu-NSG) Mouse Model for HIV Replication and Latency Studies

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HisgAtlas 1.0: a human immunosuppression gene database.

Yuan Liu¹, Mengqi He¹, Dan Wang¹

¹State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences, Beijing Institute of Lifeomics, Beijing 102206, China.

Database : the Journal of Biological Databases and Curation

|November 15, 2019

Summary

HisgAtlas is a new database that consolidates 995 human immunosuppression genes identified through text mining and manual curation. This resource aids researchers in exploring immunosuppression gene functions and potential therapeutic applications.

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Area of Science:

Immunology
Genetics
Bioinformatics

Background:

Immunosuppression, a weakened immune state, is linked to numerous human diseases.
Understanding immunosuppression genes is crucial for developing immunotherapies.
Existing data on these genes is fragmented across extensive scientific literature.

Purpose of the Study:

To create a centralized, searchable database of human immunosuppression genes.
To facilitate research into the functions and therapeutic potential of these genes.

Main Methods:

Utilized text mining techniques to identify relevant genes.
Employed manual curation to ensure data accuracy and completeness.
Compiled a comprehensive collection of 995 human immunosuppression genes.

Main Results:

Developed the HisgAtlas database, a novel resource for human immunosuppression genes.
Successfully collected and curated 995 relevant genes from scientific publications.

Conclusions:

HisgAtlas provides a valuable, consolidated resource for researchers studying immunosuppression.
The database supports further investigation into immunosuppression gene functions and their roles in disease and therapy.