Determining the Polymorphism Information Content of a molecular marker
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Updated: Jan 3, 2026

An Allele-specific Gene Expression Assay to Test the Functional Basis of Genetic Associations
Published on: November 3, 2010
Caetano Miguel Lemos Serrote1, Lia Rejane Silveira Reiniger2, Karol Buuron Silva2
1Departamento de Silvicultura e Maneio Florestal, Faculdade de Ciências Agrárias, Universidade Lúrio, Campus Universitário, Unango, Mozambique; Núcleo de Biotecnologia e Melhoramento, Universidade Federal de Santa Maria, Campus Sede, Santa Maria, RS, Brazil.
Abstract:
This review was carried out with the purpose of contributing to the discussion on the equations used in calculating the Polymorphism Information Content (PIC) of molecular markers. PIC measures the ability of a marker to detect polymorphisms, and therefore has enormous importance in selecting markers for genetic studies. We perform a summary analysis of PIC and its difference in relation to heterozygosity, another parameter used to evaluate the quality of a marker, presenting and discussing the several equations registered in the literature for both dominant and codominant markers. Finally, we present a brief direction on estimating PIC for dominant markers.
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