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Effect of congenital toxoplasmosis on the encoding of speech in infants

Laís Ferreira1, Maria Clara da Silva Valadão2, Piotr H Skarzynski3

  • 1Speech Therapy Department, Federal University of Santa Maria, Santa Maria, Brazil.

International Journal of Pediatric Otorhinolaryngology
|November 15, 2019
PubMed

Insights

Congenital toxoplasmosis (CTP) in infants impacts auditory processing, altering the Frequency-Following Response (FFR). CTP is associated with prolonged FFR wave latencies and reduced amplitudes, indicating neurophysiological changes.

Area of Science:

  • Neuroscience
  • Audiology
  • Infectious Diseases

Background:

  • Congenital toxoplasmosis (CTP) is a parasitic infection present at birth.
  • Auditory processing in infants can be affected by various congenital conditions.
  • The Frequency-Following Response (FFR) is a neurophysiological measure of auditory pathway function.

Purpose of the Study:

  • To investigate the effect of congenital toxoplasmosis (CTP) on the Frequency-Following Response (FFR) in infants.
  • To compare FFR characteristics between infants with CTP and healthy controls.

Main Methods:

  • 11 infants with CTP and 12 healthy infants (29-90 days old) underwent FFR assessment.
  • The syllable [da] was presented monaurally at 80 dBnHL.
  • Absolute latencies, amplitudes, A-O slope, and A-O latency difference of FFR waves were analyzed.

Main Results:

  • Infants with CTP exhibited prolonged latencies for FFR waves V, A, E, F, and O.
  • Decreased amplitudes were observed for FFR waves A and F in infants with CTP.
  • A reduced A-O slope and increased A-O latency difference were noted in the CTP group.

Conclusions:

  • Congenital toxoplasmosis significantly influences Frequency-Following Response neurophysiology in infants.
  • CTP is associated with prolonged FFR wave latencies and reduced wave amplitudes.
  • These findings highlight the auditory pathway impact of CTP.
Abstract

Keywords:
Auditory. child development. infant. toxoplasmosisCongenitalHearing. evoked potentials

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