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Brain Morphology of Cannabis Users With or Without Psychosis: A Pilot MRI Study
Published on: August 18, 2020
Identifying subtypes of cannabis users based on simultaneous polysubstance use.
Christal N Davis1, Wendy S Slutske1, Nicholas G Martin2
1University of Missouri, Department of Psychological Sciences, Columbia, MO, 65211, USA.
Four cannabis user subtypes were identified, with simultaneous tobacco and cannabis use linked to the most severe problems. Genetic factors influence these distinct cannabis use patterns.
Area of Science:
- Addiction research
- Psychiatry
- Genetics
Background:
- Cannabis use often co-occurs with other substances.
- Limited research exists on cannabis user subtypes based on co-use behaviors.
Purpose of the Study:
- Identify distinct subtypes of cannabis users based on co-use and simultaneous use patterns.
- Examine correlates of these subtypes, including genetic influences.
Main Methods:
- Latent class analysis of 2590 Australian twins/siblings with lifetime cannabis use.
- Assessed adolescent and adult correlates of class membership.
- Examined twin similarity for class membership.
Main Results:
- Identified four user subtypes: alcohol co-users, simultaneous alcohol users, simultaneous tobacco users, and simultaneous alcohol, tobacco, and drug users.
- Simultaneous alcohol users had higher alcohol problem risk.
- Simultaneous tobacco and cannabis use (two subtypes) showed the most problematic outcomes.
- Genetic influences (12-58%) on cannabis use patterns were observed.
Conclusions:
- Four distinct cannabis user classes with varying risk levels were identified.
- Simultaneous tobacco and cannabis use appears particularly linked to adverse outcomes.
- Findings highlight the importance of considering co-use patterns in understanding cannabis use risks.
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