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Association of Retinal Artery Occlusion with Subclinical Coronary Artery Disease

Yong Dae Kim1,2, Yong Kyu Kim2, Yeonyee E Yoon3

  • 1Department of Ophthalmology, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seongnam, Korea.

Journal of Korean Medical Science
|November 15, 2019
PubMed

Insights

Retinal artery occlusion (RAO) is linked to a higher prevalence of hidden coronary artery disease (CAD). Patients with RAO show more extensive plaque buildup, indicating increased cardiovascular risk.

Area of Science:

  • Ophthalmology
  • Cardiology
  • Vascular Medicine

Background:

  • Retinal artery occlusion (RAO) is a serious condition affecting vision.
  • The relationship between RAO and subclinical coronary artery disease (CAD) requires further investigation.

Purpose of the Study:

  • To evaluate the association between RAO and subclinical CAD.
  • To compare the extent of coronary atherosclerosis in RAO patients versus controls.

Main Methods:

  • A cohort of 41 non-arteritic RAO patients without prior CAD symptoms was studied.
  • Coronary computed tomographic angiography (CCTA) was used to assess CAD in RAO patients and age/gender-matched controls.
  • Logistic regression analysis identified risk factors associated with CAD.

Main Results:

  • RAO patients exhibited significantly higher coronary artery calcium scores compared to controls.
  • The prevalence of obstructive CAD (≥50% stenosis) was significantly higher in RAO patients (29% vs. 15%).
  • RAO was independently associated with obstructive CAD (OR, 3.0) and extensive CAD (SIS > 4: OR, 2.8; SSS > 8: OR, 3.4).

Conclusions:

  • RAO patients present with a greater prevalence of subclinical obstructive CAD.
  • These patients have a more extensive burden of coronary artery plaques than controls.
  • Physicians should consider the heightened risk of CAD in individuals with RAO.
Abstract

Keywords:
AtherosclerosisCoronary Artery DiseaseCoronary Computed Tomographic AngiographyRetinal Artery Occlusion

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