Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Adrenal Gland Disorders01:27

Adrenal Gland Disorders

2.8K
Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
2.8K
Hypothalamic-Pituitary Axis01:37

Hypothalamic-Pituitary Axis

65.2K
The response to stress—be it physical or psychological, acute or chronic—involves activation of the Hypothalamic-Pituitary-Adrenal (HPA) axis. The HPA axis is part of the neuroendocrine system because it involves both neuronal and hormonal communication. Its function is to regulate homeostatic systems—metabolic, cardiovascular, and immune—providing the necessary means to respond to a stressor.
65.2K
Major Hormones and Their Functions01:27

Major Hormones and Their Functions

1.5K
Hormones, the biochemical messengers produced by endocrine glands, are pivotal in regulating bodily functions and maintaining homeostasis. Each hormone's balance is crucial; imbalances can lead to significant physiological disruptions. Major hormones include oxytocin, cortisol, epinephrine, estrogen, testosterone, thyroxine, growth hormone, insulin, and glucagon.
Oxytocin, produced in the hypothalamus and released by the pituitary gland, plays a role in social bonding, childbirth, and...
1.5K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

380
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
380
Obesity01:24

Obesity

1.1K
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
1.1K
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

750
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
750

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Clinicopathologic Analysis of 43 Surgically Resected Lactotroph Pituitary Neuroendocrine Tumors Stratified by Surgical Indication: A Pathologic Reappraisal of Apparent Male Aggressiveness.

The American journal of surgical pathology·2026
Same author

Clinical characterization of Japanese children with Cushing's disease.

Endocrine journal·2026
Same author

Differential reversibility of anterior and posterior pituitary dysfunction in delayed recurrent pediatric Rathke's cleft cyst.

Endocrinology, diabetes & metabolism case reports·2026
Same author

Recurrent Cushing's disease due to postoperative seeding of tumor cells in the sphenoid sinus: a case report with review of the literature.

Endocrine journal·2026
Same author

Determinants of early skeletal relapse after SSRO advancement in high-angle patients with mandibular retrognathia: A retrospective study.

JPRAS open·2026
Same author

[Functional Pituitary Adenoma/Neuroendocrine Tumors].

No shinkei geka. Neurological surgery·2026

Related Experiment Video

Updated: Jan 3, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

24.1K

Cushing's Disease.

Hiroshi Nishioka1,2, Shozo Yamada3,2

  • 1Department of Hypothalamic and Pituitary surgery, Toranomon Hospital, Tokyo 1058470, Japan.

Journal of Clinical Medicine
|November 16, 2019
PubMed
Summary
This summary is machine-generated.

Diagnosing and treating Cushing's disease (CD) is challenging, requiring expert multidisciplinary teams. Personalized treatment plans are crucial for managing this complex endocrine disorder and improving patient quality of life.

Keywords:
Cushing’s diseaseCushing’s syndromeUSP-8aggressive pituitary tumorpasireotidepituitary carcinomapituitary corticotroph tumortemozolomidetranssphenoidal surgery

More Related Videos

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

19.4K
An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

23.3K

Related Experiment Videos

Last Updated: Jan 3, 2026

A Novel Method: Super-selective Adrenal Venous Sampling
06:08

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

24.1K
Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
07:43

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas

Published on: January 17, 2018

19.4K
An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents
06:55

An Unpredictable Chronic Mild Stress Protocol for Instigating Depressive Symptoms, Behavioral Changes and Negative Health Outcomes in Rodents

Published on: December 2, 2015

23.3K

Area of Science:

  • Endocrinology
  • Neurosurgery
  • Oncology

Background:

  • Cushing's disease (CD) diagnosis and treatment are critical for patient outcomes but remain challenging.
  • High-resolution MRI may not detect all pituitary tumors responsible for CD.
  • Despite advancements, achieving complete tumor removal and managing persistent or recurrent disease requires careful consideration.

Purpose of the Study:

  • To highlight the diagnostic and therapeutic challenges in Cushing's disease.
  • To emphasize the importance of a multidisciplinary and personalized approach in managing CD.
  • To discuss current treatment strategies and future directions for CD.

Main Methods:

  • Review of diagnostic challenges, including imaging limitations.
  • Analysis of first-line surgical treatment and subsequent therapeutic options for persistent or recurrent CD.
  • Discussion of the role of multidisciplinary teams and personalized medicine.

Main Results:

  • The differential diagnosis of CD can be difficult, even with structured approaches.
  • Surgical tumor removal is the primary treatment, but recurrence necessitates further interventions.
  • Multidisciplinary management and individualized treatment plans are essential for optimal outcomes.

Conclusions:

  • Effective management of Cushing's disease requires a comprehensive, team-based, and patient-specific strategy.
  • Ongoing research into the molecular pathophysiology of CD is expected to yield improved diagnostics and therapies.
  • Addressing the complexities of CD is vital for improving patient quality of life and long-term prognosis.