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Related Experiment Videos

Mebendazole for worming mice: effectiveness and side effects.

M Baskerville1, M Wood, C M Newton

  • 1Chemical Defence Establishment, Salisbury, Wiltshire, UK.

Laboratory Animals
|July 1, 1988
PubMed
Summary
This summary is machine-generated.

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Mebendazole effectively controlled common mouse parasites but caused a high incidence of kinky tails in offspring, impacting breeding colony health.

Area of Science:

  • Veterinary Parasitology
  • Laboratory Animal Science
  • Animal Reproduction

Background:

  • Hymenolepis nana and Aspiculuris tetraptera are common helminthic parasites in laboratory mouse colonies.
  • Effective parasite control is crucial for maintaining the health and integrity of mouse breeding programs.
  • Mebendazole is an anthelmintic drug used to treat various parasitic infections.

Purpose of the Study:

  • To evaluate the efficacy of a mebendazole-treated diet for controlling Hymenolepis nana and Aspiculuris tetraptera in a mouse breeding colony.
  • To assess the potential side effects of mebendazole administration on mouse reproduction and offspring development.

Main Methods:

  • A 60 ppm mebendazole-treated diet was administered to a large mouse breeding colony.
  • A 3-generation pilot study was conducted to monitor reproductive parameters and offspring health.

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  • Incidence of specific health issues, such as kinky tails, was recorded.

    • Main Results:

    • The mebendazole-treated diet effectively controlled Hymenolepis nana and Aspiculuris tetraptera infections.
    • A pilot study showed a slight reduction in litter size and female growth rate.
    • An overall incidence of 2.07% kinky tails was observed in offspring during the pilot study.
    • Widespread use of the mebendazole diet in the entire colony resulted in a significant increase in kinky tails, reaching up to 46% in weaned offspring.

    Conclusions:

    • Mebendazole is effective in controlling Hymenolepis nana and Aspiculuris tetraptera in mice.
    • Mebendazole treatment at 60 ppm can lead to adverse effects on offspring, specifically a high incidence of kinky tail syndrome.
    • The findings suggest a need for careful consideration of mebendazole dosage and administration protocols in mouse breeding colonies to balance parasite control with animal welfare.