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Abbiategrasso Brain Bank Protocol for Collecting, Processing and Characterizing Aging Brains

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Frontotemporal dementia.

Bruce Miller¹, Jorge J Llibre Guerra²

¹Memory and Aging Center and Global Brain Health Institute, University of California, San Francisco, CA, United States.

Handbook of Clinical Neurology

|November 16, 2019

Summary

This summary is machine-generated.

Frontotemporal dementia (FTD) shares clinical features with psychiatric disorders like bipolar disorder and schizophrenia. Understanding this overlap, especially in behavioral variant FTD (bvFTD), is crucial for accurate diagnosis and treatment.

Keywords:

Apathy Behavioral Degeneration Dementia Disinhibition Executive Frontotemporal Lobar Memory

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Area of Science:

Neuroscience
Neurology
Psychiatry

Background:

Frontotemporal dementia (FTD) research indicates significant overlap with primary psychiatric disorders.
Traditional divisions between neurology and psychiatry are challenged by these findings.
The behavioral variant of FTD (bvFTD) is particularly relevant to psychiatric settings.

Purpose of the Study:

To provide an overview of FTD clinical syndromes.
To describe the links between FTD syndromes and neuroimaging findings.
To review the neuropathology and genetic factors in FTD.

Main Methods:

Syndromic analysis of FTD clinical presentations.
Correlation of clinical syndromes with neuroimaging data.
Review of neuropathological and genetic research in FTD.

Main Results:

FTD syndromes exhibit considerable overlap with primary psychiatric disorders, including bipolar affective disorder and schizophrenia.
Neuroimaging studies reveal connections between FTD syndromes and brain changes.
Neuropathological and genetic analyses provide insights into FTD's underlying mechanisms.

Conclusions:

The distinction between FTD and primary psychiatric disorders requires re-evaluation.
bvFTD, a common frontal lobe degeneration syndrome, is frequently misdiagnosed or presents in psychiatric contexts.
Integrating neurological and psychiatric perspectives is essential for managing FTD.