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Updated: Jan 3, 2026
The In ovo CAM-assay as a Xenograft Model for Sarcoma
Published on: July 17, 2013
Various CAM tumor models
Aoi Komatsu1, Yuya Higashi1, Kotaro Matsumoto1
1Institute for Integrated Cell-Material Sciences, Institute for Advanced Study, Kyoto University, Kyoto, Japan.
Abstract:
Many types of in vivo animal tumor models have been established. Among these, the chicken chorioallantoic membrane (CAM) model has proven to be particularly useful for transplanting various types of cancer cell lines or tumor tissues to study tumor formation, angiogenesis and metastasis. The CAM model is useful as an animal tumor model, as tumor could be rapidly formed. The tumor formation occurs in 3-4 days, much faster than in mouse models. In addition, the CAM model can be used for drug screening for cancer therapy. This chapter provides an overview of various types of CAM tumor models.
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