Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diabetes Mellitus: Type 2 and Gestational01:22

Diabetes Mellitus: Type 2 and Gestational

4.2K
Type 2 diabetes, characterized by insulin resistance, arises when the insulin receptors on cells lose responsiveness to insulin, diminishing the cell's capacity to take up glucose, resulting in elevated blood glucose levels. To receive a diagnosis of Type 2 diabetes, a series of blood glucose tests are necessary to assess whether the blood glucose falls within normal parameters. If the result is out of the normal range, a patient may be diagnosed as prediabetic or diabetic, depending on the...
4.2K
Diabetes: Management and Pharmacotherapy01:15

Diabetes: Management and Pharmacotherapy

817
The therapy for diabetes aims to alleviate hyperglycemia-related symptoms, prevent acute metabolic decompensation, and reduce chronic end-organ complications. Glycemic control is evaluated through short-term (self-monitoring, continuous glucose monitoring) and long-term (A1c, fructosamine) metrics, enabling near real-time tracking of blood glucose levels and reflecting glycemic control over specific time frames.
Insulin remains the cornerstone of treatment for most patients with type 1 and many...
817
Insulin: Dosing Regimen and Adverse Effects01:16

Insulin: Dosing Regimen and Adverse Effects

618
Insulin-replacement therapy usually includes both long-acting insulin (basal) and short-acting insulin (to cater to postprandial needs). In a diverse group of type 1 diabetes patients, the average daily insulin dose is typically 0.5-0.7 units/kg body weight. However, obese patients and pubertal adolescents may need more due to insulin resistance.
The basal dose constitutes about 40%-50% of the total daily dose, with the rest as premeal insulin. The mealtime insulin dose should mirror...
618
Diabetes Mellitus: Overview and Type I Subtype01:22

Diabetes Mellitus: Overview and Type I Subtype

4.8K
Diabetes mellitus is a chronic metabolic disorder characterized by high blood glucose levels due to inadequate insulin production, insulin resistance, or both. The condition affects millions worldwide and can significantly impact their health and quality of life.
Type 1 diabetes is an autoimmune disease in which the immune system mistakenly attacks and destroys the insulin-producing beta cells in the pancreas. As a result, the body is unable to produce sufficient insulin, and individuals with...
4.8K
Hypoglycemia and Glucagon01:15

Hypoglycemia and Glucagon

750
Without prolonged fasting, healthy individuals maintain blood glucose levels above 3.5 mM due to a well-adapted neuroendocrine counterregulatory system that effectively prevents acute hypoglycemia, a potentially life-threatening condition. The primary clinical scenarios for hypoglycemia encompass diabetes treatment, inappropriate production of endogenous insulin or insulin-like substances by tumors, and the use of glucose-lowering agents in non-diabetic individuals. Notably, hypoglycemia in the...
750
Carbohydrate Metabolism01:36

Carbohydrate Metabolism

13.6K
Carbohydrates are polymers composed of molecules containing atoms of carbon, hydrogen and oxygen. One gram of carbohydrate can provide four kilo-calories of energy, which makes it the most efficient instant energy source.
Starch accounts for approximately 60% of the carbohydrates consumed by humans. Since amylase enzymes cannot function in the stomach's acidic environment, starch can only be digested in the mouth and small intestine. Simple sugars are found naturally in milk and fruits in...
13.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Factors associated with infection-related hospitalisations in severe mental illness: a retrospective cohort study.

BMJ mental health·2026
Same author

Hypoglycaemia Was Not Associated With Depression, Anxiety, Diabetes Distress or Fear of Hypoglycaemia Scores in People With Type 1 or Insulin-Treated Type 2 Diabetes in the Hypo-METRICS Study.

Diabetes, obesity & metabolism·2026
Same author

Effectiveness of the Responding to Experienced and Anticipated Discrimination (READ) training on reducing stigma for medical students in Tunisia.

PloS one·2026
Same author

Gender differences in hypoglycaemia in type 1 and insulin-treated type 2 diabetes: the Hypo-METRICS study.

Diabetologia·2026
Same author

Psychoeducation for adults with type 1 diabetes and problematic hypoglycemia: implementation analysis of a clinical trial (HARPdoc).

Frontiers in health services·2026
Same author

Comment on Thomas et al. Measuring Impaired Awareness of Hypoglycemia.

Diabetes care·2026

Related Experiment Video

Updated: Jan 3, 2026

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.3K

Effectiveness-implementation hybrid type 2 trial evaluating two psychoeducational programmes for severe hypoglycaemia

Tayana Soukup1, Louise Hull2, Emma Lauretta Smith3,4

  • 1Centre for Implementation Science, Health Service and Population Research Department, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK tayana.soukup@kcl.ac.uk.

BMJ Open
|November 16, 2019
PubMed
Summary
This summary is machine-generated.

This study evaluates two programs, HARPdoc and BGAT, to improve hypoglycemia awareness in type 1 diabetes. It aims to develop a blueprint for implementing effective interventions, enhancing patient safety and diabetes management.

Keywords:
diabetes & endocrinologyprotocols & guidelines

More Related Videos

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health
06:13

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health

Published on: December 1, 2023

1.5K
A Method for Manipulating Blood Glucose and Measuring Resulting Changes in Cognitive Accessibility of Target Stimuli
08:01

A Method for Manipulating Blood Glucose and Measuring Resulting Changes in Cognitive Accessibility of Target Stimuli

Published on: August 12, 2016

9.4K

Related Experiment Videos

Last Updated: Jan 3, 2026

Improving IV Insulin Administration in a Community Hospital
12:08

Improving IV Insulin Administration in a Community Hospital

Published on: June 11, 2012

19.3K
Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health
06:13

Author Spotlight: Exploring the Impact of Reduced Resistance Exercise Volume on Metabolic Health

Published on: December 1, 2023

1.5K
A Method for Manipulating Blood Glucose and Measuring Resulting Changes in Cognitive Accessibility of Target Stimuli
08:01

A Method for Manipulating Blood Glucose and Measuring Resulting Changes in Cognitive Accessibility of Target Stimuli

Published on: August 12, 2016

9.4K

Area of Science:

  • Diabetes Management
  • Clinical Psychology
  • Implementation Science

Background:

  • Hypoglycemia and severe hypoglycemia (SH) are feared complications in type 1 diabetes (T1D).
  • Impaired awareness of hypoglycemia (IAH) increases SH risk, yet current education lacks behavioral change techniques.
  • A novel Hypoglycaemia Awareness Restoration Programme despite optimised care (HARPdoc) integrates these techniques.

Purpose of the Study:

  • To evaluate the delivery of HARPdoc and Blood Glucose Awareness Training (BGAT).
  • To explore associations between implementation outcomes and trial endpoints for T1D complications.
  • To develop an evidence-based blueprint for effective program implementation and scale-up.

Main Methods:

  • Utilizing implementation science frameworks and mixed-methods approach.
  • Conducting focus groups with stakeholders, including individuals with T1D and healthcare professionals.
  • Engaging stakeholders throughout the study design to maximize relevance and feasibility.

Main Results:

  • Pre-results data available.
  • The study is ongoing, focusing on implementation and trial endpoints.
  • Analysis will explore associations between implementation and effectiveness.

Conclusions:

  • The study will provide insights into delivering and scaling effective hypoglycemia management programs for T1D.
  • Findings will inform future strategies to reduce hypoglycemia, SH, and IAH in adults with T1D.
  • An implementation blueprint will guide sustained use of effective interventions.