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Complete Genome Sequence of Klebsiella pneumoniae Myophage Mulock

Lorna Min1, Lauren Lessor1, Chandler O'Leary1

  • 1Center for Phage Technology, Texas A&M University, College Station, Texas, USA.

Microbiology Resource Announcements
|November 16, 2019
PubMed

Insights

This study details the genome of Mulock, a temperate bacteriophage infecting Klebsiella pneumoniae. Mulock shows distant relation to other Klebsiella phages and partial synteny with Escherichia phage lambda.

Area of Science:

  • Microbiology
  • Virology
  • Genomics

Background:

  • Klebsiella pneumoniae is a significant opportunistic pathogen.
  • This bacterium is frequently implicated in hospital-acquired infections.

Purpose of the Study:

  • To describe the complete genome sequence of the K. pneumoniae myophage Mulock.
  • To analyze its phylogenetic relationship with other bacteriophages.

Main Methods:

  • Whole-genome sequencing of myophage Mulock.
  • Comparative genomic analysis.

Main Results:

  • The complete genome of myophage Mulock was elucidated.
  • Mulock is a temperate myophage.
  • Phylogenetic analysis indicates a distant relationship to other Klebsiella phages, particularly in morphogenesis genes.
  • Partial synteny was observed with Escherichia phage lambda in genes encoding lambda-like functions.

Conclusions:

  • The genome sequence provides a basis for understanding Mulock's biology.
  • Mulock represents a distinct lineage within Klebsiella phages.
  • Its genetic features suggest potential evolutionary links to other phage groups.

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