Potential savings through single-dose intravenous Dalbavancin in long-term MRSA infection treatment - a health

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A Reference Broth Microdilution Method for Dalbavancin In Vitro Susceptibility Testing of Bacteria that Grow Aerobically
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A Reference Broth Microdilution Method for Dalbavancin In Vitro Susceptibility Testing of Bacteria that Grow Aerobically

Published on: September 9, 2015

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Michael Wilke1, Kerstin Worf1, Birgit Preisendörfer1

  • 1inspiring-health GmbH, Munich, Germany.

GMS Infectious Diseases
|November 16, 2019
PubMed

Insights

Single-dose Dalbavancin effectively treats complicated skin and bone infections caused by MRSA, reducing hospital stays and costs. This approach allows for earlier patient discharge, offering significant economic benefits in Germany.

Area of Science:

  • Infectious Diseases
  • Pharmacoeconomics
  • Antimicrobial Therapy

Background:

  • Complicated infections like osteomyelitis, skin, and soft tissue infections (ABSSSI) and joint, bone, and prostheses infections (JBPI) necessitate prolonged antibiotic treatment.
  • Extended hospital length of stay (LOS) associated with these infections significantly increases healthcare costs.
  • Methicillin-resistant Staphylococcus aureus (MRSA) is a common pathogen in these complicated infections.

Purpose of the Study:

  • To evaluate the economic impact of single-dose intravenous Dalbavancin for treating MRSA infections in Germany.
  • To assess the potential for cost savings and reduced LOS associated with Dalbavancin therapy in specific patient groups.

Main Methods:

  • Analysis of real-world patient treatment data in Germany.
  • Validation of findings in a large German hospital setting.
  • Focus on patients with acute bacterial skin, skin structure and soft tissue infections (ABSSSI) and joint, bone, and prostheses infections (JBPI) caused by MRSA.

Main Results:

  • Patients with MRSA-related ABSSSI treated with single-dose Dalbavancin experienced a 6.45-day shorter LOS, saving €2,865 per patient.
  • Patients with MRSA-related JBPI treated with single-dose Dalbavancin had an average earlier discharge of 10.6 days, saving €3,909 per patient.
  • Single-dose Dalbavancin facilitates earlier patient discharge, demonstrating significant cost-effectiveness.

Conclusions:

  • Single-dose intravenous Dalbavancin is an economically viable treatment option for eligible patients with MRSA-related ABSSSI and JBPI in Germany.
  • The use of Dalbavancin can lead to substantial reductions in hospital LOS and associated healthcare expenditures.
  • This therapeutic approach supports earlier discharge, optimizing resource utilization in managing complex infections.
Keywords:
cost savingshealth economic modellength of staysingle-dose intravenous Dalbavancin

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