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Halogenated Agent Delivery in Porcine Model of Acute Respiratory Distress Syndrome via an Intensive Care Unit Type Device
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Sedation strategies in children with pediatric acute respiratory distress syndrome (PARDS)

Lynne Rosenberg1, Chani Traube1

  • 1Department of Pediatrics, Weill Cornell Medical College, New York, NY, USA.

Annals of Translational Medicine
|November 16, 2019
PubMed

Insights

Current pediatric acute respiratory distress syndrome (PARDS) sedation strategies shift from deep benzodiazepine use to lighter sedation with agents like dexmedetomidine. Monitoring sedation, analgesia, withdrawal, and delirium is key for better outcomes.

Area of Science:

  • Pediatric critical care medicine
  • Pharmacology
  • Respiratory medicine

Background:

  • Traditional mechanical ventilation in pediatric acute respiratory distress syndrome (PARDS) involved deep sedation using benzodiazepines.
  • Emerging evidence suggests potential harms associated with deep sedation and prolonged benzodiazepine use in critically ill children.

Purpose of the Study:

  • To review the evolving strategies for sedation in mechanically ventilated children with PARDS.
  • To highlight the shift towards lighter sedation and the use of non-benzodiazepine agents.
  • To emphasize comprehensive monitoring for improved patient outcomes.

Main Methods:

  • Literature review of recent studies and clinical guidelines on sedation in PARDS.
  • Analysis of the benefits and risks of different sedating agents.
  • Discussion of multimodal monitoring parameters.

Main Results:

  • Emerging literature supports lighter sedation protocols over deep sedation for PARDS.
  • Dexmedetomidine and other non-benzodiazepine agents show promise in PARDS sedation.
  • Comprehensive monitoring of sedation depth, analgesia, opiate withdrawal, and delirium is crucial.

Conclusions:

  • The optimal sedation strategy for PARDS is shifting towards lighter, more targeted approaches.
  • Non-benzodiazepine sedatives like dexmedetomidine represent a valuable option.
  • Further research is necessary to refine sedation protocols and improve outcomes in pediatric patients with PARDS.

Keywords:
Pediatric acute respiratory distress syndrome (PARDS)analgesiadeliriumsedation

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