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Colonic Perforation as Initial Presentation of Amyloid Disease: Case Report and Literature Review

A Ussia1, S Vaccari1, A Lauro2

  • 1Department of Emergency Surgery, St. Orsola University Hospital, Bologna, Italy.

Digestive Diseases and Sciences
|November 16, 2019
PubMed
Abstract

Insights

Primary amyloidosis of the colon is rare and can cause spontaneous intestinal perforation, necessitating surgical intervention. This case highlights potential complications like ostomy stenosis requiring further procedures.

Area of Science:

  • Gastroenterology
  • Pathology
  • Surgical Oncology

Background:

  • Amyloidosis is characterized by amyloid fibril deposition in tissues, rarely requiring surgery unless complications arise.
  • Primary amyloidosis of the colon is an uncommon manifestation of this systemic disease.

Observation:

  • A patient with polymyositis and primary colon amyloidosis presented with spontaneous colonic perforation.
  • The patient underwent a Hartmann's procedure for the perforation.

Findings:

  • Following the initial surgery, the patient experienced a 2-month period of well-being.
  • The patient subsequently required two additional surgical procedures due to stenosis of the ostomy orifice.

Implications:

  • Gastrointestinal amyloid disease is a rare cause of intestinal perforation, emphasizing the need for timely surgical management.
  • This case underscores potential postoperative complications in patients with amyloidosis, such as ostomy-related issues.
Keywords:
Amyloid diseasePerforationSurgery

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