Recurrence pattern and outcomes in T4 colon cancer: A single institution analysis

Area of Science:

• Oncology
• Gastroenterology
• Surgical Oncology

Background:

• T4 colon adenocarcinoma presents a significant challenge due to high rates of locoregional and distant recurrence.
• Understanding the metastatic patterns and predictors of recurrence is vital for improving patient outcomes.

Purpose of the Study:

• To define the metastatic pattern in T4 colon adenocarcinoma.
• To identify predictors of recurrence and mortality in patients with T4 colon cancer.
• To evaluate the efficacy of adjuvant treatment strategies.

Main Methods:

• Retrospective review of patients diagnosed with T4 colon adenocarcinoma between May 2005 and November 2015.
• Analysis of baseline factors, follow-up data, recurrence patterns, and survival outcomes.
• Multivariate analysis to identify significant predictors of recurrence and mortality.

Main Results:

• Locoregional recurrence rates increased with lymph node positivity (N0: 24.7%, N1: 28%, N2: 45.7%).
• Positive nodes, perforation, lymphovascular invasion, and positive margins were significant predictors of recurrence.
• Signet ring histology, positive nodes, and positive margins were associated with decreased overall survival.

Conclusions:

• T4 colon adenocarcinoma is associated with a high risk of locoregional recurrence and mortality.
• Identifying high-risk features is essential for stratifying patients and designing future clinical trials.
• Further research and clinical trials focusing on these high-risk features may improve intervention efficacy.