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Preparation and Pathogen Inactivation of Double Dose Buffy Coat Platelet Products using the INTERCEPT Blood System
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Impact of implementing pathogen reduction technologies for platelets on reducing outdates.

Carlos Gorria1, Gorka Labata2, Mikel Lezaun1

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Extending platelet concentrate shelf life to seven days with pathogen reduction technologies (PRT) can drastically cut waste. Optimal production logistics, including daily or targeted PRT application, are key to minimizing outdates.

Keywords:
mathematical simulationoptimizationplatelet concentrate stocks

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Area of Science:

  • Blood banking and transfusion medicine
  • Biotechnology and medical device technology

Background:

  • Platelet concentrates (PC) typically have a 5-day shelf life.
  • Pathogen reduction technologies (PRT) can extend PC shelf life to 7 days.
  • Limited studies exist on PRT's impact on PC outdate rates.

Purpose of the Study:

  • To evaluate the impact of PRT on platelet outdate rates using mathematical simulation.
  • To determine optimal production strategies to minimize PC waste.

Main Methods:

  • Mathematical simulation modeling.
  • Statistical analysis to determine daily production rates.
  • Analysis of demand, donation limitations, and minimum stock requirements.

Main Results:

  • A 2-day shelf life extension (to 7 days) reduced PC outdates by 88.4% to 100% in analyzed centers.
  • If less than 25% of PCs are treated annually, concentrating PRT on the last two production days is most effective.
  • If over 25% of PCs are treated annually, daily PRT application is preferable.

Conclusions:

  • Extending PC shelf life to 7 days significantly reduces outdates.
  • Implementing appropriate production logistics is crucial for minimizing waste.
  • Strategic PRT application, either daily or targeted before weekends, optimizes outdate reduction.