Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Fatigue01:21

Fatigue

775
Fatigue occurs when materials rupture under repeated or fluctuating loads, even at stress levels far below their static breaking strength. It typically results in brittle failure, even for ductile materials. It is a critical consideration in designing machines and structural components subjected to repetitive or varying loads. The nature of these loadings can range from fluctuating loads like unbalanced pump impellers causing vibrations to repeatedly bending a thin steel rod wire back and forth...
775
Muscle Recovery and Fatigue01:24

Muscle Recovery and Fatigue

3.9K
Muscle fatigue refers to the decline in a muscle's ability to maintain the force of contraction after prolonged activity. It primarily stems from changes within muscle fibers. Even before experiencing muscle fatigue, one may feel tired and have the urge to stop the activity. This response, known as central fatigue, occurs due to changes in the central nervous system, namely the brain and spinal cord. While there is no single mechanism that induces fatigue, it may serve as a protective...
3.9K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Effectiveness of Personalized Robot-Assisted Rehabilitation on Fall Risk: A Retrospective Controlled Study with a 6-Month Follow-Up.

Sensors (Basel, Switzerland)·2026
Same author

Long-Term Ravulizumab Efficacy and Safety in AQP4 Antibody-Positive Neuromyelitis Optica Spectrum Disorder: Final CHAMPION-NMOSD Results.

Neurology(R) neuroimmunology & neuroinflammation·2026
Same author

Critical care outcomes of hemophagocytic lymphohistiocytosis in children: a single centre retrospective observational study.

Pediatric rheumatology online journal·2026
Same author

Triple-crush mechanism in multiple sclerosis-associated trigeminal neuralgia.

Journal of neurology·2026
Same author

The relationship between cerebellar functional connectivity alterations and hand dexterity impairment in multiple sclerosis.

Journal of neurology·2026
Same author

From Marginal to Central: Marginal Zone-like B Cells as Critical Targets in Cladribine-Treated Multiple Sclerosis.

Annals of neurology·2026

Related Experiment Video

Updated: Jan 3, 2026

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer
07:22

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

6.1K

Cognitive fatigability is a quantifiable distinct phenomenon in multiple sclerosis.

Silvia Tommasin1, Francesca De Luca2,3, Ilaria Ferrante2

  • 1Department of Human Neurosciences, Sapienza University of Rome, Italy.

Journal of Neuropsychology
|November 16, 2019
PubMed
Summary

Cognitive fatigability in multiple sclerosis, a decline in cognitive performance, can now be objectively measured. This new method quantifies fatigability, revealing it as a distinct issue, particularly in those with preserved cognition.

Keywords:
Symbol Digit Modalities Testcognitive fatigabilityfatiguemodellingmultiple sclerosis

More Related Videos

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

58.6K
The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
09:25

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

19.9K

Related Experiment Videos

Last Updated: Jan 3, 2026

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer
07:22

Measuring the Motor Aspect of Cancer-Related Fatigue using a Handheld Dynamometer

Published on: February 20, 2020

6.1K
The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool
11:35

The Multiple Sclerosis Performance Test MSPT: An iPad-Based Disability Assessment Tool

Published on: June 30, 2014

58.6K
The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse
09:25

The Treadmill Fatigue Test: A Simple, High-throughput Assay of Fatigue-like Behavior for the Mouse

Published on: May 31, 2016

19.9K

Area of Science:

  • Neuroscience
  • Clinical Psychology
  • Rehabilitation Medicine

Background:

  • Cognitive fatigability is a common, debilitating symptom in multiple sclerosis (MS).
  • It significantly impacts patients' quality of life and work capacity.
  • Currently, objective measures for cognitive fatigability are lacking.

Purpose of the Study:

  • To develop and validate a method for quantifying cognitive fatigability in MS.
  • To differentiate cognitive fatigability from general cognitive impairment.
  • To investigate if cognitive fatigability is an independent phenomenon.

Main Methods:

  • Information processing speed was assessed using the Symbol Digit Modalities Test (SDMT).
  • Performance (number of correct answers) was recorded every 30 seconds over 180 seconds.
  • Logarithmic models, including a second-order term, were used to approximate performance over time and quantify fatigability (coefficient B).

Main Results:

  • A novel second-order least squares fit model was proposed to quantify cognitive fatigability.
  • Cognitively preserved MS patients exhibited a performance deflection (fatigability) not seen in controls or impaired patients.
  • This fatigability (B) was independent of depression and general fatigue, and more pronounced in cognitively preserved individuals.

Conclusions:

  • Cognitive fatigability in MS can be objectively quantified using a second-order logarithmic model.
  • Cognitive fatigability is a free-standing phenomenon, distinct from overall cognitive impairment.
  • This quantifiable measure is practical for clinical use and highlights fatigability's prevalence in cognitively preserved MS patients.