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Biomarkers of fungal infection: Expert opinion on the current situation

E Bouza1, B Almirante, J García Rodríguez

  • 1Emilio Bouza, Instituto de Investigación Sanitaria Gregorio Marañón, Servicio de Microbiología Clínica y E. Infecciosas, C/ Dr. Esquerdo, 46, 28007 Madrid, Spain. emilio.bouza@gmail.com.

Revista Espanola De Quimioterapia : Publicacion Oficial De La Sociedad Espanola De Quimioterapia
|November 16, 2019
PubMed

Insights

Non-culture-based fungal biomarkers are revolutionizing diagnostics. This expert review addresses the combined use and impact of multiple fungal biomarker negativity on antifungal treatment decisions.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Biomarker Discovery

Background:

  • Non-culture-based diagnostic techniques are transforming microbiological diagnosis.
  • Fungal biomarkers offer significant potential for improved management of fungal infections.
  • Current evaluation of fungal biomarkers often lacks robust study designs and focuses on individual use.

Framework:

  • This document synthesizes expert opinions on the clinical utility of fungal biomarkers.
  • It addresses the current knowledge gaps regarding the combined use of multiple biomarkers.
  • Expert consensus is sought due to the scarcity of high-quality, prospective studies.

Implementation:

  • Experts from diverse fields convened to discuss invasive fungal infections.
  • The focus is on answering key questions regarding the current application of fungal biomarkers.
  • The review consolidates insights into practical diagnostic and treatment strategies.

Implications:

  • Understanding the combined value of fungal biomarkers can refine diagnostic accuracy.
  • Assessing the impact of negative biomarker results is crucial for optimizing antifungal therapy.
  • This expert-driven summary provides guidance for clinical decision-making in invasive fungal infections.
Keywords:
1-3ß-D-GlucanAnti-MannanCAGTACandidemiaCritical CareGalactomannanIntensive CareInvasive candidiasisInvasive fungal infectionsMannanT2Candidaantifungal stewardshipfungal biomarkersinvasive aspergillosis

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