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Vaccinations

Vaccinations

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Hexavalent Vaccines in India: Current Status.

Amar Jeet Chitkara¹, Raunak Parikh², Attila Mihalyi³

¹Department of Pediatrics, Max Superspeciality Hospital, Delhi, India.

Indian Pediatrics

|November 16, 2019

Summary

This summary is machine-generated.

Hexavalent vaccines offer a simplified immunization schedule for infants and toddlers in India. Acellular pertussis-based hexavalent vaccines demonstrate superior pertussis response rates compared to whole-cell vaccines.

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Area of Science:

Immunology
Vaccinology
Pediatrics

Background:

Hexavalent vaccines combine diphtheria, tetanus, pertussis, Haemophilus influenzae type b, poliomyelitis, and hepatitis B antigens.
Three hexavalent vaccines are available in India: DTwP-Hib/HepB-IPV (wP-hexa), DTaP-IPV-HB-PRP~T(2aP-hexa), and DTaP-HBV-IPV/Hib (3aP-hexa).

Purpose of the Study:

To evaluate the immunogenicity and safety of hexavalent vaccines for primary immunization series and booster doses in India.
To compare the efficacy of different hexavalent vaccine formulations.

Main Methods:

Phase-3 Indian studies assessed pertussis vaccine response rates and seroprotection for other antigens after a 6-10-14 week primary series.
External studies evaluated booster dosing, immune persistence, and co-administration with other vaccines.

Main Results:

Acellular pertussis-based hexavalent vaccines (2aP-hexa, 3aP-hexa) showed significantly higher pertussis response rates (93.8-100%) compared to whole-cell pertussis-based (wP-hexa) vaccine (68.4-75.7%).
Seroprotection rates for other antigens ranged from 49.6% to 100% across different vaccines.
Studies indicated good immunogenicity and safety for booster doses, with sustained immune responses for up to 15 years for certain antigens.

Conclusions:

Hexavalent vaccines, particularly acellular pertussis formulations, are effective for primary immunization in India.
These vaccines simplify vaccination schedules, potentially improving compliance and reducing the number of injections.
Further research supports their use for booster doses and co-administration with other pediatric vaccines.