Secondary Metabolites Produced by an Endophytic Fungus Pestalotiopsis microspora
G R Nalin Rathnayake1, N Savitri Kumar1, Lalith Jayasinghe2
1National Institute of Fundamental Studies, Hantana Road, Kandy, Sri Lanka.
Abstract:
An endophytic fungus Pestalotiopsis microspora isolated from the fruits of Manilkara zapota was cultured in potato dextrose broth media. Chromatographic separation of the EtOAc extract of the broth and mycelium led to the isolation of a new azaphilonoid named pitholide E (1), in addition to previously identified pitholide B (2), pitholide D (3), pestalotin (LL-P880α) (4), PC-2 (5), LL-P880β (6), tyrosol (7) and 4-oxo-4H-pyran-3-acetic acid (8). An endophytic fungus P. microspora from M. zapota and the isolation of compounds 1-5, 7 and 8 from P. microspora are reported here for the first time.
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