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Updated: Jan 3, 2026
Quantitative and Qualitative Method for Sphingomyelin by LC-MS Using Two Stable Isotopically Labeled Sphingomyelin Species
Published on: May 7, 2018
The Use of DMS-MS for the Quantitative Analysis of Acylcarnitines
Nicholas B Vera1,2, Michelle Clasquin3, Stephen L Coy4
1Cambridge Laboratories, Pfizer Global Research and Development, Pfizer Inc., Cambridge, MA, USA. nicholas.b.vera@pfizer.com.
Abstract:
Differential mobility spectrometry (DMS) is capable of separating molecules based on their size and shape. When coupled to mass spectrometry (MS), DMS reduces chemical background and enhances signal-to-noise (S/N) ratio. Flow injection analysis (FIA) is a technique used to introduce samples into the source of the DMS-MS platform. Here we describe the application of FIA-DMS-MS/MS for the analysis of urinary acylcarnitine species. More than 20 acylcarnitine species can be detected and quantified during a single FIA-DMS-MS/MS acquisition.
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