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Published on: October 2, 2020
Lipid and oxidative profile in hemodialysis patients: Clinical follow-up for three years
Insights
Hemodialysis patients show increased lipid peroxidation, a marker of oxidative stress. After three years, these oxidative stress biomarkers, malondialdehyde (MDA) and conjugated dienes (CD), significantly worsen.
Area of Science:
- Nephrology
- Cardiovascular Medicine
- Biochemistry
Background:
- Cardiovascular morbidity is a leading cause of mortality in hemodialysis (HD) patients.
- Oxidative stress (OS) is closely linked to cardiovascular complications in HD patients.
Purpose of the Study:
- To assess lipid peroxidation biomarkers, specifically malondialdehyde (MDA) and conjugated dienes (CD), in hemodialysis patients.
- To monitor changes in these lipid peroxidation markers over a three-year period in patients undergoing hemodialysis.
Main Methods:
- Inclusion of 100 end-stage renal disease patients on regular hemodialysis and 100 healthy controls.
- Measurement of routine chemical data, lipid profiles, and levels of MDA and CD in both groups.
Main Results:
- Hemodialysis patients exhibited significantly elevated plasma and erythrocyte MDA levels compared to healthy subjects (p <0.001).
- Increased erythrocyte CD levels were also significantly higher in HD patients (p<0.001).
- A significant increase in lipid peroxidation biomarkers was observed after three years of follow-up.
Conclusions:
- A notable disturbance in the lipid peroxidation status was identified in hemodialysis patients.
- Oxidative stress becomes more pronounced over time, evidenced by a significant increase in MDA and CD levels at the three-year follow-up.
Background:
The major cause of death for hemodialysis (HD) patients was cardiovascular morbidity; it was closely related to oxidative stress (OS).
Aim:
Firstly, to evaluate lipid peroxidation biomarkers on HD patients through measuring malondialdehyde (MDA) and conjugated dienes (CD), and secondly, to follow these parameters after three years undergoing HD.
Methods:
One hundred patients with end stage renal diseases receiving regular hemodialysis and 100 healthy volunteers were included in this study. Routine chemical data, lipid profile and levels of MDA and CD were measured.
Results:
The plasmatic and erythrocyte MDA levels were significantly increased in the HD patients compared to healthy subjects (p <0.001). However, an increased level on erythrocyte CD was only observed between the two study groups (p<0.001). After 3 years, a significant increased level of lipid peroxidation biomarkers was observed.
Conclusion:
The disturbance in lipid peroxidation state in HD patients was observed. At three years follow-up, oxidative stress is more pronounced with a significant increase in MDA and CD.
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