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Updated: Jan 3, 2026

Paramagnetic Relaxation Enhancement for Detecting and Characterizing Self-Associations of Intrinsically Disordered Proteins
Published on: September 23, 2021
Adding diffusion ordered NMR spectroscopy (DOSY) to the arsenal for characterizing paramagnetic complexes
M P Crockett1, H Zhang, C M Thomas
1Department of Chemistry, Boston College, Eugene F. Merkert Chemistry Center, 2609 Beacon Street, Chestnut Hill, Massachusetts 02467, USA. Jeffery.byers@bc.edu.
Abstract:
Herein we report the development of diffusion ordered NMR spectroscopy (DOSY) for its use to characterize metal complexes containing paramagnetic first row transition metal elements. This technique is capable of assessing the purity and speciation of paramagnetic complexes, and also provides a convenient method to provide qualitative and sometimes quantitative molecular weight data.
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