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Using Coculture to Detect Chemically Mediated Interspecies Interactions
Published on: October 31, 2013
Chemical Reporters for Exploring Microbiology and Microbiota Mechanisms
Zhenrun J Zhang1, Yen-Chih Wang1, Xinglin Yang1
1Laboratory of Chemical Biology and Microbial Pathogenesis, The Rockefeller University, 1230 York Avenue, New York, NY, 10065, USA.
Abstract:
The advances made in bioorthogonal chemistry and the development of chemical reporters have afforded new strategies to explore the targets and functions of specific metabolites in biology. These metabolite chemical reporters have been applied to diverse classes of bacteria including Gram-negative, Gram-positive, mycobacteria, and more complex microbiota communities. Herein we summarize the development and application of metabolite chemical reporters to study fundamental pathways in bacteria as well as microbiota mechanisms in health and disease.
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