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Related Concept Videos

Thermosensation01:43

Thermosensation

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Peripheral thermosensation is the perception of external temperature. A change in temperature (on the surface of the skin and other tissues) is detected by a family of temperature-sensitive ion channels called Transient Receptor Potential, or TRP, receptors. These receptors are located on free nerve endings. Those detecting cold temperatures are closer to the surface of the skin than the nerve endings detecting warmth. These thermoTRP channels, while temperature selective, have relatively...
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Sorting nexin 11 knockout mice exhibit enhanced thermosensing behaviour.

Hua-Lin Huang1,2,3, Caiyue Li1,2, Wenbo Ma1,2

  • 1Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China.

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Sorting nexin 11 (SNX11) protein regulates temperature perception by controlling TRPV3 ion channel levels. Mice lacking SNX11 show altered responses to heat, indicating SNX11

Keywords:
TRPV3 ion channelsmouse behaviourplasma membranesorting nexin 11temperature sensing

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Area of Science:

  • Physiology
  • Neuroscience
  • Molecular Biology

Background:

  • Temperature sensing is crucial for warm-blooded animals, involving ThermoTRP ion channels activated by physiological temperatures.
  • Sorting nexin 11 (SNX11) was previously identified to regulate the degradation of TRPV3, a key temperature-sensing ion channel protein.

Purpose of the Study:

  • To investigate the role of SNX11, a vesicular trafficking protein, in modulating mouse behavior and thermal perception.
  • To elucidate the molecular mechanisms by which SNX11 influences the function and expression of TRPV3 channels.

Main Methods:

  • Behavioral analysis of Snx11-knockout mice in response to varying temperatures.
  • Electrophysiological recordings of temperature-gated TRPV3 currents in keratinocytes.
  • Assessment of TRPV3 protein expression levels in keratinocytes and skin tissues.

Main Results:

  • Snx11-knockout mice displayed a heightened preference for mild temperatures and increased sensitivity to harmful heat.
  • Keratinocytes from knockout mice showed augmented temperature-gated TRPV3 membrane currents and elevated TRPV3 expression at the plasma membrane.
  • Higher overall TRPV3 protein levels were observed in the skin tissues of Snx11-knockout mice compared to wild-type controls.

Conclusions:

  • SNX11 plays a significant role in regulating thermal perception and associated mouse behaviors.
  • The findings suggest SNX11 modulates thermal transduction by altering the abundance of functional TRPV3 channels on the plasma membrane.
  • This study establishes the first link between vesicular trafficking mechanisms and thermal sensory transduction via TRPV3 regulation.