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PD-1 Inhibitors: Safety of Use and Management of Immune-Mediated Adverse Reactions in Patients With Head and Neck

Rebecca L Lewis1, Kristen L Miller2

  • 1University of Pittsburgh Medical Center Hillman Cancer Center.

Clinical Journal of Oncology Nursing
|November 16, 2019
PubMed
Abstract

Insights

Nurses play a vital role in managing immune-mediated adverse reactions (IMARs) in patients receiving programmed cell death protein 1 (PD-1) inhibitors for head and neck cancers. Early identification and patient education are key to effective IMAR treatment.

Area of Science:

  • Oncology
  • Immunotherapy
  • Nursing Care

Background:

  • Treatment of recurrent or metastatic squamous cell carcinoma of the head and neck (SCCHN) with programmed cell death protein 1 (PD-1) inhibitors carries a risk of immune-mediated adverse reactions (IMARs).
  • Understanding and managing these IMARs is crucial for patient safety and treatment efficacy.

Purpose of the Study:

  • To provide nurses with an overview of the safety of PD-1 inhibitors for SCCHN.
  • To offer recommendations for the diagnosis and management of IMARs in patients receiving PD-1 inhibitors.

Main Methods:

  • Literature review using PubMed® searches.
  • Review of drug manufacturer algorithms for IMAR management.

Main Results:

  • Nurses should assess baseline patient profiles to aid in timely IMAR diagnosis and treatment.
  • Patient and caregiver education on recognizing IMAR signs and symptoms is essential.
  • Nurses are integral to efficient IMAR management, minimizing treatment interruptions.

Conclusions:

  • Proactive nursing involvement in monitoring and managing IMARs is critical for patients undergoing PD-1 inhibitor therapy for SCCHN.
  • Effective nursing strategies can optimize patient outcomes and maintain the continuity of immunotherapy.
Keywords:
PD-1 inhibitorsimmune-mediated adverse reactionssquamous cell carcinoma

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