Related Experiment Video

Updated: Jan 3, 2026

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up
09:01

Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up

Published on: March 26, 2018

14.6K

Mesenchymal stem cells in acute myeloid leukemia: a focus on mechanisms involved and therapeutic concepts

Ezzatollah Fathi1, Zohreh Sanaat2, Raheleh Farahzadi2

  • 1Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Tabriz, Tabriz, Iran.

Blood Research
|November 16, 2019
PubMed

Insights

Mesenchymal stem cells (MSCs) show promise in treating leukemia by suppressing tumor cell proliferation. This review details MSCs

Area of Science:

  • Oncology
  • Stem Cell Biology
  • Cancer Therapeutics

Background:

  • Drug resistance in leukemia presents significant treatment challenges.
  • Mesenchymal stem cells (MSCs) are being investigated as a novel therapeutic approach.
  • MSC heterogeneity may impact treatment outcomes, necessitating further research.

Purpose of the Study:

  • To review the anti-tumorigenic effects of MSCs in hematologic malignancies.
  • To elucidate the mechanisms by which MSCs suppress cancer cell proliferation.
  • To focus on the application of MSCs in treating acute myeloid leukemia.

Main Methods:

  • Literature review of studies on MSCs and hematologic malignancies.
  • Analysis of proposed mechanisms of MSC anti-tumorigenic activity.
  • Synthesis of current understanding of MSC-based therapies for leukemia.

Main Results:

  • MSCs demonstrate anti-proliferative effects on hematologic cancer cells.
  • The primary mechanism involves inducing tumor cell cycle arrest.
  • MSC therapy shows potential for acute myeloid leukemia treatment.

Conclusions:

  • MSCs offer a promising strategy for combating hematologic malignancies like acute myeloid leukemia.
  • Targeting tumor cell proliferation via MSCs is a key therapeutic avenue.
  • Further research into MSC mechanisms and standardization is warranted.
Keywords:
Acute myeloid leukemiaCancer therapyCell cycle arrestHematologic malignancyMesenchymal stem cells

More Related Videos

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies06:33

Author Spotlight: Analyzing Bone Marrow Microenvironment in Murine Hematological Malignancies

Published on: November 10, 2023

1.7K
Simplified Intrafemoral Injections Using Live Mice Allow for Continuous Bone Marrow Analysis06:28

Simplified Intrafemoral Injections Using Live Mice Allow for Continuous Bone Marrow Analysis

Published on: November 10, 2023

3.6K

Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
5.4K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.5K
Bone Marrow Sampling and Transplants01:22

Bone Marrow Sampling and Transplants

Bone marrow transplant is a potential cure for several diseases, including cancer and specific genetic disorders. Notably, this procedure is applicable for patients suffering from aplastic anemia, certain types of leukemia, severe combined immunodeficiency disease (SCID), Hodgkin's disease, non-Hodgkin's lymphoma, multiple myeloma, thalassemia, sickle-cell disease, and certain cancers.
The transplant begins with high doses of chemotherapy and radiation treatment, which aim to destroy...
788
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.8K
Multipotency of Hematopoietic Stem Cells01:19

Multipotency of Hematopoietic Stem Cells

The hematopoietic stem cells or HSCs are multipotent, meaning they can differentiate and give rise to all blood and immune cells. HSCs are maintained in the quiescent stage until an external stimulus initiates their differentiation. The multipotent HSCs exist as two heterogeneous populations, long-term repopulating cells (LTRC) and short-term repopulating cells (STRC). The two HSC populations have different surface markers or receptors and are classified based on quiescence and long-term...
3.7K
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.8K