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Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages
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Investigation of Macrophage Polarization Using Bone Marrow Derived Macrophages

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Macrophage polarization in atherosclerosis

Sai Yang1, Hou-Qin Yuan1, Ya-Meng Hao1

  • 1Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerosis of Hunan Province, University of South China, Hengyang City, Hunan Province, 421001, PR China.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|November 16, 2019
PubMed

Insights

Regulating macrophage polarization offers a novel therapeutic strategy for atherosclerosis. Modifying macrophage phenotypes within plaques can reduce plaque size and improve stability, aiding cardiovascular disease treatment.

Area of Science:

  • Cardiovascular Science
  • Immunology
  • Pathogenesis of Atherosclerosis

Background:

  • Atherosclerosis is a chronic inflammatory condition linked to cardiovascular diseases.
  • Macrophage polarization and phenotype are critical to atherosclerosis development and progression.
  • Understanding macrophage roles is key to treating atherosclerotic cardiovascular disease.

Purpose of the Study:

  • To review the intricate relationship between macrophage polarization and atherosclerosis.
  • To explore therapeutic strategies targeting macrophage polarization in atherosclerosis treatment.
  • To provide a new perspective on atherosclerosis therapy by focusing on macrophage modulation.

Main Methods:

  • Literature review on macrophage polarization in atherosclerosis.
  • Analysis of studies investigating the impact of macrophage phenotypes on plaque development.
  • Synthesis of research on therapeutic interventions targeting macrophage polarization.

Main Results:

  • Macrophage polarization significantly influences the pathogenesis of atherosclerosis.
  • The balance of macrophage phenotypes within atherosclerotic plaques affects disease severity.
  • Modulating macrophage polarization has shown potential in reducing plaque size and enhancing plaque stability.

Conclusions:

  • Regulating macrophage polarization presents a promising therapeutic avenue for atherosclerosis.
  • Targeting macrophage phenotypes offers a novel approach to managing atherosclerotic cardiovascular disease.
  • Future research should focus on translating macrophage polarization modulation into clinical treatments.

Keywords:
AtherosclerosisMacrophage polarizationPhenotype

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