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Activated protein C assays: A review
Julia Oto1, Álvaro Fernández-Pardo1, Manuel Miralles2
1Haemostasis, Thrombosis, Atherosclerosis and Vascular Biology Research Group, Medical Research Institute Hospital La Fe (IIS La Fe), Valencia, Spain.
Clinica Chimica Acta; International Journal of Clinical Chemistry
|November 16, 2019
Summary
Activated protein C (APC), an anticoagulant, has protective functions beyond blood clotting. Measuring APC levels is crucial for understanding its role in various diseases and developing new therapies.
Area of Science:
- Biochemistry
- Pharmacology
- Medical Science
Background:
- Activated protein C (APC) is a key anticoagulant that regulates thrombin generation.
- Deficiencies in APC or its precursor, protein C (PC), elevate the risk of venous thromboembolism.
- APC exhibits cytoprotective effects, leading to its investigation in severe sepsis and inflammatory conditions.
Purpose of the Study:
- To review and compare existing methods for quantifying circulating Activated protein C (APC) in plasma.
- To highlight the advantages, disadvantages, and clinical utility of various APC measurement assays.
Main Methods:
- Review of approximately 16 reported methods for APC quantification.
- Analysis of assay implementation stages and suitability for different applications.
Main Results:
- Multiple methods exist for APC measurement, each with unique strengths and weaknesses.
- The choice of assay depends on the specific application and desired clinical relevance.
Conclusions:
- Accurate measurement of APC is essential for its therapeutic development and clinical application.
- Understanding the nuances of different APC assays is critical for advancing research in thrombosis, inflammation, and other related diseases.
