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Close to the Bone: Tissue-Specific Checkpoint Immunotherapy Evasion

Vincenzo Bronte1

  • 1Department of Medicine of University of Verona, Policlinico GB Rossi, Piazzale L.A. Scuro 10, 37134 Verona, Italy.

Cell
|November 16, 2019
PubMed

Insights

Immune checkpoint therapy resistance can depend on where cancer spreads. Bone metastases create a hostile environment, hindering treatment effectiveness.

Area of Science:

  • Oncology
  • Immunology
  • Cancer Metastasis

Background:

  • Immune checkpoint inhibitors (ICIs) have revolutionized cancer treatment.
  • Resistance to ICIs is a significant clinical challenge.
  • Tumor microenvironment heterogeneity influences treatment response.

Purpose of the Study:

  • To investigate the impact of metastatic site on immune checkpoint therapy resistance.
  • To characterize the bone microenvironment's role in treatment resistance.

Main Methods:

  • Analysis of primary tumors versus bone metastases.
  • Assessment of immune cell infiltration and function in different metastatic sites.
  • In vivo and in vitro models to study the bone metastatic niche.

Main Results:

  • The location of metastases significantly influences ICI resistance.
  • Bone metastases establish a particularly hostile microenvironment.
  • Specific cellular and molecular factors within bone promote resistance.

Conclusions:

  • Metastatic site is a critical determinant of immune checkpoint therapy efficacy.
  • Targeting the bone microenvironment may overcome resistance.
  • Future strategies should consider the metastatic niche in treatment design.

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