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The link between bipolarity and substance use: A controlled clinic based study.

Anoop Krishna Gupta1, Subodh B N2, Abhishek Ghosh2

  • 1Department of Psychiatry, National Medical College Teaching Hospital, Birganj, Nepal.

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Summary

Substance use and bipolar disorder may share a common origin in bipolarity, suggesting a continuum. This study found a significant association between bipolarity and substance use disorders in male patients.

Keywords:
Bipolar spectrum disorderBipolarityMood dysregulationSubstance use disorder

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Area of Science:

  • Psychiatry
  • Neuroscience
  • Addiction Medicine

Background:

  • Substance use disorder (SUD) and bipolar disorder (BPAD) share high co-occurrence rates, familial risk, and phenotypic similarities.
  • These conditions may originate from a common substrate in bipolarity, potentially existing on a continuum.

Purpose of the Study:

  • To investigate the association between bipolarity and substance use.
  • To explore the potential continuum between substance use and bipolar disorder.

Main Methods:

  • Cross-sectional study comparing bipolarity as a trait in four groups: SUD, BPAD, dual diagnosis (DD), and healthy controls (HC).
  • Utilized the Bipolar Spectrum Diagnostic Scale (BSDS) and the WHOQOL-Bref scale for quality of life assessment.

Main Results:

  • The mean BSDS score was significantly higher in SUD (11.0±5.3) compared to HC (6.2±3.9).
  • BSDS scores were higher in BPAD (18.4±4.2) and DD (20.6±3.6) groups than in the SUD group, with no significant difference between BPAD and DD.
  • A significant association was found between substance dependence and bipolarity.

Conclusions:

  • Mood dysregulation appears to link substance dependence and bipolarity.
  • The findings suggest a continuum model between substance use and bipolar disorder, as indicated by BSDS scores.
  • This clinic-based study focused exclusively on male patients.