Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clostridium difficile in preterm neonates.

R Cardines1, I Luzzi, G Menichella

  • 1Laboratorio di Batteriologia e Micologia Medica, Istituto Superiore di Sanita, Roma, Italy.

Microbiologica
|July 1, 1988
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Molecular characterization and antibiotic resistance of salmonella serovars isolated in the Apulia region of Italy.

Journal of biological regulators and homeostatic agents·2017
Same author

A novel group of IncQ1 plasmids conferring multidrug resistance.

Plasmid·2016
Same author

Reference intervals for HbA1c partitioned for gender and age: a multicenter study.

Acta diabetologica·2016
Same author

Characterisation of Yersinia pseudotuberculosis isolated from animals with yersiniosis during 1996-2013 indicates the presence of pathogenic and Far Eastern strains in Italy.

Veterinary microbiology·2015
Same author

Characterization of an unusual Salmonella phage type DT7a and report of a foodborne outbreak of salmonellosis.

International journal of food microbiology·2014
Same author

Lactobacillus brevis CD2 inhibits Prevotella melaninogenica biofilm.

Oral diseases·2013

Toxigenic Clostridium difficile was found in 63% of premature infants. This colonization was linked to bowel disorders and antibiotic use, suggesting these factors promote harmful C. difficile strains.

Area of Science:

  • Neonatal Medicine
  • Microbiology
  • Infectious Diseases

Background:

  • Clostridium difficile is a significant cause of neonatal infections.
  • Premature neonates are a vulnerable population for gastrointestinal issues.
  • Understanding C. difficile colonization in neonates is crucial for infection control.

Purpose of the Study:

  • To determine the prevalence of toxigenic Clostridium difficile in premature neonates.
  • To investigate the correlation between C. difficile colonization and neonatal bowel disorders.
  • To assess the role of antibiotic administration in C. difficile colonization.

Main Methods:

  • Stool specimens from premature neonates were analyzed for C. difficile.
  • Strain differentiation was performed using SDS-PAGE, antibiotic susceptibility, and toxin production assays.

Related Experiment Videos

  • Colonization rates were compared between infants with and without bowel disorders and antibiotic treatment.

    • Main Results:

    • A high isolation rate of 63% for Clostridium difficile was observed.
    • No significant difference in incidence was found between infants treated or not with antibiotics.
    • Toxigenic C. difficile strains were exclusively found in infants with bowel disorders and antibiotic treatment.

    Conclusions:

    • Antibiotic use and bowel disorders may favor colonization by toxigenic Clostridium difficile strains in premature neonates.
    • Early identification and management of C. difficile are essential in neonatal care.
    • Further research is needed to elucidate the precise mechanisms of C. difficile pathogenesis in this population.