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Related Experiment Video

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Large-scale Recording of Neurons by Movable Silicon Probes in Behaving Rodents
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Open source silicon microprobes for high throughput neural recording.

Long Yang1, Kwang Lee1, Jomar Villagracia2

  • 1Equal contribution.

Journal of Neural Engineering
|November 16, 2019
PubMed
Summary
This summary is machine-generated.

We developed and openly shared silicon microprobes for high-throughput neural recording. This open-source approach makes advanced brain recording tools accessible to researchers, accelerating neuroscience discovery.

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Area of Science:

  • Neuroscience
  • Bioengineering
  • Materials Science

Background:

  • High-throughput extracellular neural recording is crucial for understanding brain function.
  • Commercialization of novel electrode-based tools faces adoption barriers in the neuroscience community.

Purpose of the Study:

  • To describe the development, application, and open dissemination of silicon microprobes for in vivo neural activity recording.
  • To propose an open-source platform as an alternative to commercialization for wider tool adoption.

Main Methods:

  • In-house design of silicon microprobes with third-party fabrication for mass production.
  • Integration of microprobes with optical fibers for optogenetics and fiber photometry.
  • Establishment of an online repository for design, usage, and sharing resources.

Main Results:

  • Demonstrated silicon microprobes with up to 256 electrodes for neural recording.
  • Provided insights into the relationship between calcium activity and neural spiking.
  • Showcased the dissemination status and accessibility of these tools.

Conclusions:

  • Silicon microprobes offer a promising, accessible alternative to existing high-throughput neural recording technologies.
  • Open dissemination accelerates the adoption and advancement of neuroscience research tools.
  • Validating fiber photometry with electrophysiological recordings is essential.