Genomic Perspective on Mouse Liver Cancer Models

Area of Science:

• Oncology
• Genomics
• Translational Research

Background:

• Hepatocellular carcinoma (HCC) is a complex disease with diverse molecular subtypes.
• Accurate preclinical mouse models are essential for translating research findings into clinical applications.
• Current mouse models often lack sufficient recapitulation of human HCC heterogeneity.

Purpose of the Study:

• To review and identify mouse models that closely mimic human hepatocellular carcinoma (HCC).
• To align mouse models with specific HCC molecular subtypes and histologic aggressiveness.
• To facilitate the selection of appropriate models for preclinical studies and clinical translation.

Main Methods:

• Comprehensive review of existing literature on HCC mouse models.
• Integration of genomic data from human HCC with characteristics of mouse models.
• Comparative analysis of molecular subtypes and histologic features.

Main Results:

• Identification of specific mouse models that recapitulate distinct HCC molecular subtypes.
• Evaluation of models based on their ability to reflect HCC biology and prognosis.
• Highlighting gaps in current mouse model representation of human HCC.

Conclusions:

• Selecting HCC mouse models based on molecular subtypes and aggressiveness is critical.
• This review provides a guide for choosing models that enhance the predictive value of preclinical studies.
• Improved model selection will accelerate the translation of HCC research into effective clinical strategies.