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A Real-time Potency Assay for Chimeric Antigen Receptor T Cells Targeting Solid and Hematological Cancer Cells
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Targeting CXCR1/2: The medicinal potential as cancer immunotherapy agents, antagonists research highlights and

Jinxin Che1, Rui Song2, Binhui Chen1

  • 1ZJU-ENS Joint Laboratory of Medicinal Chemistry, Zhejiang Province Key Laboratory of Anti-Cancer Drug Research, Hangzhou Institute of Innovative Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, 310058, China.

European Journal of Medicinal Chemistry
|November 17, 2019
PubMed

Insights

Targeting CXCR1/2 receptors can overcome immune suppression in the tumor microenvironment (TME). This review details CXCR1/2 antagonists for cancer immunotherapy, discussing drug development, clinical progress, and challenges.

Area of Science:

  • Oncology
  • Immunology
  • Medicinal Chemistry

Background:

  • Tumor microenvironment (TME) immune suppression hinders anti-cancer immunotherapy effectiveness.
  • Chemokine receptors CXCR1 and CXCR2 mediate the recruitment of immunosuppressive myeloid-derived suppressor cells (MDSCs) to the TME.

Purpose of the Study:

  • To review the medicinal chemistry of CXCR1/2 antagonists.
  • To summarize their relevance and development in cancer immunotherapy.
  • To discuss clinical status and challenges.

Main Methods:

  • Literature review of CXCR1/2 antagonists.
  • Analysis of medicinal chemistry strategies.
  • Evaluation of clinical trial data.

Main Results:

  • CXCR1/2 antagonists represent a promising therapeutic strategy.
  • Several drug candidates have advanced in development.
  • Understanding design rationale is key to overcoming challenges.

Conclusions:

  • CXCR1/2 antagonists offer a viable approach to reversing TME-mediated immune suppression.
  • Further development is warranted to address clinical challenges and optimize efficacy.
Keywords:
CXCR1/2 antagonistsCancerClassificationsClinical developmentImmunotherapy

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