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Binding partners of NRF2: Functions and regulatory mechanisms

Le Ba Nam1, Young-Sam Keum1

  • 1College of Pharmacy and Integrated Research Institute for Drug Development, Dongguk University, 32 Dongguk-ro, Goyang, Gyeonggi-do, 10326, South Korea.

Archives of Biochemistry and Biophysics
|November 17, 2019
PubMed

Insights

Nuclear factor erythroid 2-related factor 2 (NRF2) is crucial for cellular protection against oxidants. This study identifies NRF2

Area of Science:

  • Molecular Biology
  • Cellular Biology
  • Biochemistry

Background:

  • Nuclear factor erythroid 2-related factor 2 (NRF2) is a key transcription factor regulating cellular defense against oxidative and electrophilic stress.
  • Elevated NRF2 levels are implicated in cancer chemoresistance and radioresistance.
  • NRF2 influences critical cellular processes beyond redox balance, including autophagy, apoptosis, cell cycle, and stem cell differentiation.

Purpose of the Study:

  • To identify and summarize the direct binding partners of NRF2.
  • To elucidate the mechanisms by which these binding partners interact with NRF2.
  • To understand how NRF2 binding partners regulate NRF2 stability and activity.

Main Methods:

  • Literature review and synthesis of existing research on NRF2 binding proteins.
  • Analysis of protein-protein interaction data.
  • Functional analysis of NRF2 and its partners.

Main Results:

  • Identification of several direct binding partners of NRF2.
  • Detailed description of the binding interfaces and interactions.
  • Explanation of how these interactions modulate NRF2's role in cellular processes.

Conclusions:

  • NRF2's functions are significantly mediated by its direct binding partners.
  • Understanding these interactions is crucial for targeting NRF2 in cancer therapy.
  • Further research into NRF2-protein interactions can reveal new therapeutic strategies.
Keywords:
Antioxidant response element (ARE)Binding partnersNF-E2-related factor 2 (NRF2)NRF2-ECH homology (Neh) domains

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