A simple mathematical model for relapsing-remitting multiple sclerosis (RRMS)
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Updated: Jan 3, 2026

A Method of Trigonometric Modelling of Seasonal Variation Demonstrated with Multiple Sclerosis Relapse Data
Published on: December 9, 2015
1Mathematics Department, Faculty of Science, King Khalid University, Abha 9004, Saudi Arabia; Mathematics Department, Faculty of Science, Mansoura University, Mansoura 35516, Egypt.
Abstract:
Multiple sclerosis is one of the most common autoimmune-related neurological disorders affecting the central nervous system. One of its main properties is dissemination of lesions in time and space. Here, we propose a simple mathematical model to describe the stages of disease progression with recurrence. We tried to find the steady states and evaluated their stability to identify the necessary conditions to produce the recurrence. Also, we described the analytical results with some numerical simulations.
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