Related Experiment Video

Updated: Aug 13, 2026

Antigenic Liposomes for Generation of Disease-specific Antibodies
10:31

Antigenic Liposomes for Generation of Disease-specific Antibodies

Published on: October 25, 2018

Which value of antigenic valency should be used in antibody avidity calculations with multivalent antigens?

M H van Regenmortel1

  • 1Laboratoire d'Immunochimie, Institut de Biologie Moléculaire et Cellulaire, Strasbourg, France.

Molecular Immunology
|June 1, 1988
PubMed

The calculation of antibody avidity for multivalent antigens requires the experimental determination of the antigenic valency by extrapolation of Scatchard plots of the type f/d versus f. At any ratio of the reactants, the antigenic valency corresponds to the maximum number of antibody molecules that can be bound simultaneously. In spite of the steric hindrance effect that is prevalent with multivalent antigens, the antigenic valency is a constant parameter and not a variable influenced by the ratio of antibody to antigen.

More Related Videos

Rapid Determination of Antibody-Antigen Affinity by Mass Photometry10:17

Rapid Determination of Antibody-Antigen Affinity by Mass Photometry

Published on: February 8, 2021

An Open-Source Framework for Mass Calculation of Antibody-Based Therapeutic Molecules04:24

An Open-Source Framework for Mass Calculation of Antibody-Based Therapeutic Molecules

Published on: June 16, 2023

Related Concept Videos

Affinity and Avidity01:41

Affinity and Avidity

Overview
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and reactivity.
Antibody Actions01:26

Antibody Actions

Antibodies, or immunoglobulins, are critical players in the immune system's arsenal against invading pathogens. Produced by B cells and plasma cells, their primary role is to detect and bind to specific antigens, molecules found on the surface of pathogens like bacteria or viruses. Beyond antigen recognition, antibodies perform several vital functions that contribute to immune defense.
Neutralization
Antibodies can bind to pathogens, preventing them from infecting host cells. This process...