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Cytogenetic effects of acrylamide in the bone marrow of mice
1Research Institute for Organic Syntheses, Department of Toxicology, Pardubice-Rosice, Czechoslovakia.
Mutation Research
|September 1, 1988
Abstract:
A single i.p. injection of 100 mg/kg acrylamide monomer elevated the frequency of chromosome aberrations and micronucleated polychromatic erythrocytes in the bone marrow of male ICR mice. A positive relationship between frequency of micronuclei and dose of acrylamide was obtained in the dose range of 2 x 25, 2 x 50 and 2 x 100 mg/kg.