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Updated: Jan 3, 2026

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
Coronary angiography in the setting of acute infective endocarditis requiring surgical treatment
Clémence Laperche1, Olivier Lairez2, Jean Ferrieres3
1Department of Cardiology, Rangueil University Hospital, 31059 Toulouse, France.
Insights
Preoperative coronary angiography in infective endocarditis patients is safe and provides crucial information for surgical planning. This diagnostic approach aids in identifying coronary artery disease, guiding treatment decisions, and improving patient outcomes.
Area of Science:
- Cardiology
- Cardiac Surgery
- Infectious Diseases
Background:
- International guidelines suggest preoperative coronary angiography for infective endocarditis patients needing surgery.
- Potential risks include contrast-induced nephropathy and vegetation embolization, especially with aortic endocarditis.
Purpose of the Study:
- To evaluate the safety and effectiveness of coronary angiography in patients with active infective endocarditis scheduled for surgery.
- To assess its therapeutic implications and impact on patient prognosis.
Main Methods:
- Retrospective monocentric study of 193 patients with active endocarditis and surgical indication (Jan 2013 - Feb 2017).
- Coronary angiography performed in 142 patients (73.6%), primarily via radial approach (91.6%).
- Coronary multislice computed tomography used in 14 patients.
Main Results:
- 10.6% experienced acute renal failure; 1.4% had a stroke post-angiography; no complications in aortic endocarditis patients.
- Surgery was performed on 178 patients (92.2%).
- Significant coronary lesions found in 19.7%; 14.0% underwent coronary artery bypass grafting.
Conclusions:
- Preoperative coronary angiography in infective endocarditis is safe.
- It yields significant information for a substantial number of patients.
- This procedure aids in surgical decision-making and management planning.
Background:
International guidelines recommend that preoperative coronary angiography is performed on patients at risk of coronary disease who have infective endocarditis requiring surgical treatment. However, the risks of contrast-induced nephropathy or vegetation embolization in case of aortic endocarditis should be considered.
Aims:
To assess the safety, therapeutic implications and prognostic impact of coronary angiography in patients requiring surgical treatment for active infective endocarditis.
Methods:
This retrospective monocentric study was conducted in patients referred to a tertiary care centre for active endocarditis management with a theoretical indication for surgery between January 2013 and February 2017.
Results:
One hundred and ninety-three patients were included; 73.1% were men, the mean age was 61.9±16.3 years and the median EuroSCORE II was 5.8%. One hundred and nineteen patients (61.7%) had aortic endocarditis, which was associated with aortic vegetation in 74 cases (38.3%). Invasive coronary angiography was performed in 142 patients (73.6%) - 130 (91.6%) by radial approach - and 14 patients were evaluated by coronary multislice computed tomography (one patient had exploration with both techniques). Acute renal failure after coronary angiography was observed in 15 patients (10.6%), two patients (1.4%) presented a stroke within 24h after coronary angiography, but none had aortic endocarditis. Among the 178 patients (92.2%) who underwent surgery, 35 (19.7%) had significant coronary lesion(s) and 25 (14.0%) underwent an associated coronary artery bypass graft.
Conclusions:
Preoperative coronary angiography in patients affected by infective endocarditis provides relevant information in a significant proportion of patients and can be performed safely.
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