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Systemic and Local Drug Delivery for Treating Diseases of the Central Nervous System in Rodent Models
Published on: August 16, 2010
Sequential drug delivery for liver diseases.
Xiaozhong Huang1, Fan Lee2, Yao Teng1
1Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, MD9-04-11, 2 Medical Drive, Singapore 117593, Singapore; Institute of Bioengineering and Nanotechnology, A*STAR, The Nanos, #06-01, 31 Biopolis Way, Singapore 138669, Singapore.
Advanced Drug Delivery Reviews
|November 18, 2019
Summary
Sequential drug delivery in the liver is crucial due to rapid metabolism and short drug exposure. This review explores advanced biomaterials, cells, and microdevices for effective sequential drug administration in liver diseases.
Area of Science:
- Hepatology
- Pharmacology
- Biomaterials Science
Background:
- The liver's high blood flow and rapid drug metabolism necessitate novel drug delivery strategies.
- Short drug exposure times in liver cells limit the efficacy, potency, and safety of conventional treatments.
- Understanding liver regeneration and disease progression is key to developing targeted therapies.
Purpose of the Study:
- To review sequential drug delivery strategies for liver diseases.
- To highlight advancements in biomaterial, cell, and microdevice-based platforms for rapid drug delivery and switching.
- To explore potential applications of sequential drug delivery in liver cancer, viral hepatitis, fatty liver disease, and drug-induced liver injury.
Main Methods:
- Review of existing literature on sequential drug delivery in liver regeneration and disease.
- Analysis of various delivery platforms including biomaterials, cells, and microdevices.
- Comparative assessment of delivery kinetics and drug switching capabilities.
Main Results:
- Various platforms show promise for localized, sequential drug delivery in the liver.
- Fast delivery kinetics and rapid drug switching are achievable with advanced systems.
- Examples include applications in liver cancer, hepatitis B, fatty liver disease, and drug-induced liver injury.
Conclusions:
- Sequential drug delivery offers a promising approach to overcome challenges in treating liver diseases.
- Further development of biomaterial, cell, and microdevice platforms is warranted.
- This nascent field holds significant potential for improving therapeutic outcomes in hepatology.
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