Related Experiment Videos
Selection criteria for radical prostatectomy based on morphometric studies in prostate carcinoma
F S Freiha1, J E McNeal, T A Stamey
1Department of Surgery, Stanford University School of Medicine, CA 94305-5118.
NCI Monographs : a Publication of the National Cancer Institute
|January 1, 1988
Summary
Radical prostatectomy for prostate cancer cure is recommended for tumors under 3.8 cm3. Accurate pre-surgical tumor volume assessment requires further research priority.
Area of Science:
- Urology
- Oncology
- Pathology
Background:
- Prostate cancer management relies on accurate tumor assessment.
- Tumor volume, seminal vesicle invasion, lymph node metastasis, and capsular penetration are critical prognostic factors.
Purpose of the Study:
- To correlate morphometric tumor volume with pathological findings in radical prostatectomy specimens.
- To establish a threshold for tumor volume in patients undergoing radical prostatectomy for cure.
Main Methods:
- Morphometric analysis of 122 radical prostatectomy specimens.
- Evaluation of cancer volume, grade, seminal vesicle invasion, lymph node metastasis, and capsular penetration.
Main Results:
- Mean cancer volume varied significantly based on pathological findings: 3.7 cm3 (no invasion/metastasis), 9.0 cm3 (SV invasion only), 15.2 cm3 (LN metastasis only), and 17.8 cm3 (both).
- Tumor volume strongly correlated with cancer grade.
- Specimens without capsular penetration had a mean volume of 2.5 cm3, versus 9.0 cm3 with penetration.
Conclusions:
- Radical prostatectomy for cure is advisable for tumors less than 3.8 cm3.
- Prioritizing research into pre-surgical tumor volume assessment methods is crucial for optimizing treatment decisions.