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Measurement of Tissue Non-Heme Iron Content using a Bathophenanthroline-Based Colorimetric Assay

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Published on: January 31, 2022

Hydroxyurea-induced hyperpigmentation with iron deposition.

Kevin P Lee¹, Ramya K Vangipuram, Natasha K Klimas

¹McGovern Medical School, Houston, TX. kevin.p.lee@uth.tmc.edu.

Dermatology Online Journal

|November 19, 2019

Summary

This summary is machine-generated.

Hydroxyurea can cause skin hyperpigmentation, a known side effect. This case reveals hydroxyurea-induced hyperpigmentation is linked to iron deposition, a mechanism previously associated with other drugs.

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Area of Science:

Dermatology
Hematology
Pharmacology

Background:

Hydroxyurea is a chemotherapeutic agent used for hematological disorders and psoriasis.
Cutaneous side effects of hydroxyurea include hyperpigmentation, xerosis, and dermal ulcers.
Hydroxyurea-induced hyperpigmentation typically involves increased melanin production.

Observation:

Diffuse hyperpigmentation is a recognized side effect of hydroxyurea.
Iron deposition in the dermis is a known cause of diffuse hyperpigmentation, classically linked to minocycline.
A novel case of hydroxyurea-induced hyperpigmentation associated with dermal iron deposition was observed.

Findings:

The study presents a unique case linking hydroxyurea treatment to hyperpigmentation.
Histopathological examination revealed iron deposition in the dermis, a finding not previously associated with hydroxyurea-induced hyperpigmentation.
This challenges the established understanding of hydroxyurea's cutaneous side effects.

Implications:

This finding expands the differential diagnosis for drug-induced hyperpigmentation.
It suggests a potential mechanism for hydroxyurea-induced hyperpigmentation beyond melanin increase.
Further research is warranted to elucidate the role of iron deposition in hydroxyurea-related skin changes.