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Related Experiment Video

Updated: Jan 3, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
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Vision and Hyper-Responsiveness in Migraine.

Amelia Aldrich1, Paul Hibbard1, Arnold Wilkins1

  • 1Department of Psychology, University of Essex, Wivenhoe Park, Essex, Colchester CO4 3SQ, UK.

Vision (Basel, Switzerland)
|November 19, 2019
PubMed
Summary
This summary is machine-generated.

Migraine patients with aura show enhanced contrast perception in the affected visual field. Comfortable colored lenses, however, normalize this enhanced perception, suggesting a link between cortical hyper-responsiveness and contrast sensitivity.

Keywords:
contrast discriminationcortical hyperexcitabilitymigraine aura

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Area of Science:

  • Neuroscience
  • Ophthalmology
  • Visual Perception

Background:

  • Migraine is a neurological disorder associated with cortical hyperexcitability.
  • Visual discomfort and altered sensory processing are common in migraineurs.
  • The relationship between contrast processing, visual comfort, and migraine remains incompletely understood.

Purpose of the Study:

  • To investigate contrast processing in individuals with migraine with and without aura.
  • To explore the impact of colored light on visual comfort and contrast perception in migraineurs.
  • To determine if specific light colors can modulate the enhanced contrast sensitivity observed in migraine with aura.

Main Methods:

  • Experiment 1: Contrast discrimination task in migraine with aura (MA), migraine without aura (MO), and healthy controls.
  • Experiment 2: Assessment of comfortable light color preferences in MA, MO, and controls.
  • Experiment 3: Contrast discrimination with comfortable colored lenses versus neutral grey lenses in individuals with unilateral aura.

Main Results:

  • No significant group differences in overall contrast discrimination, but superior performance in the aura-affected visual field for participants with consistently lateralized aura.
  • Individuals with aura preferred more saturated colors distant from the daylight locus compared to controls.
  • Comfortable colored lenses reduced the enhanced contrast discrimination in the aura-affected visual field, normalizing performance in individuals with unilateral aura.

Conclusions:

  • Cortical hyper-responsiveness in migraine may enhance contrast perception.
  • Ophthalmic lenses with comfortable colors can modulate and normalize the heightened contrast sensitivity in migraine with aura.
  • These findings suggest a potential therapeutic role for specific light filtering in managing visual disturbances in migraine.