Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Vestibular System01:29

The Vestibular System

43.1K
The vestibular system is a set of inner ear structures that provide a sense of balance and spatial orientation. This system is comprised of structures within the labyrinth of the inner ear, including the cochlea and two otolith organs—the utricle and saccule. The labyrinth also contains three semicircular canals—superior, posterior, and horizontal—that are oriented on different planes.
43.1K
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.1K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.1K
Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

909
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
909
Glaucoma: Overview01:25

Glaucoma: Overview

1.2K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.2K
Equilibrium and Balance01:15

Equilibrium and Balance

6.1K
The inner ear assumes dual functionalities of auditory perception and equilibrium maintenance. The vestibule is the organ responsible for balance. This organ contains mechanoreceptors, specifically hair cells, endowed with stereocilia, which aid in deciphering information regarding the position and motion of our heads. Two intrinsic components, the utricle and saccule, help perceive head position, while the semicircular canals track head movement. Neurological messages initiated in the...
6.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Efficacy of IncobotulinumtoxinA (BoNT-A) Injections in Upper Limb Task-Specific and Position-Dependent Tremors.

Movement disorders clinical practice·2026
Same author

Efficacy and outcomes of 360° laser retinopexy versus focal laser photocoagulation for retinal detachment.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie·2026
Same author

Concurrent validity estimates for the accuracy of administrative data case definitions for uveitis in Ontario, Canada.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie·2026
Same author

Guiding syringe selection for intravitreal injections: injectability and stability analysis of compounded pegcetacoplan (SYFOVRE) and the broader implications for high-viscosity ophthalmic therapies.

International journal of retina and vitreous·2026
Same author

Disease burden associated with X-linked retinitis pigmentosa in Canada: a retrospective chart review study.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie·2025
Same author

Contrasting approaches to estimate the epidemiology of uveitis in Canadian health administrative data.

Canadian journal of ophthalmology. Journal canadien d'ophtalmologie·2025

Related Experiment Video

Updated: Jan 3, 2026

Three Dimensional Vestibular Ocular Reflex Testing Using a Six Degrees of Freedom Motion Platform
10:12

Three Dimensional Vestibular Ocular Reflex Testing Using a Six Degrees of Freedom Motion Platform

Published on: May 23, 2013

16.3K

Image Stabilization in Central Vision Loss: The Horizontal Vestibulo-Ocular Reflex.

Esther G González1,2,3, Runjie Shi4, Luminita Tarita-Nistor1,3

  • 1Krembil Research Institute, Toronto Western Hospital, Toronto, ON M5T 2S8, Canada.

Vision (Basel, Switzerland)
|November 19, 2019
PubMed
Summary
This summary is machine-generated.

Patients with central vision loss use their preferred retinal locus (PRL) for visual direction, even in darkness. This eccentric vision strategy impacts their vestibulo-ocular reflex (VOR) responses.

Keywords:
age-related macular degenerationcentral vision losseye movementspreferred retinal locusvestibulo-ocular reflex

More Related Videos

Assessing Binocular Central Visual Field and Binocular Eye Movements in a Dichoptic Viewing Condition
07:45

Assessing Binocular Central Visual Field and Binocular Eye Movements in a Dichoptic Viewing Condition

Published on: July 21, 2020

4.9K
Using Eye-tracking to Assess the Relative Importance of Visual and Vestibular Input to Subcortical Motion Processing in the Roll Plane
07:24

Using Eye-tracking to Assess the Relative Importance of Visual and Vestibular Input to Subcortical Motion Processing in the Roll Plane

Published on: August 22, 2025

415

Related Experiment Videos

Last Updated: Jan 3, 2026

Three Dimensional Vestibular Ocular Reflex Testing Using a Six Degrees of Freedom Motion Platform
10:12

Three Dimensional Vestibular Ocular Reflex Testing Using a Six Degrees of Freedom Motion Platform

Published on: May 23, 2013

16.3K
Assessing Binocular Central Visual Field and Binocular Eye Movements in a Dichoptic Viewing Condition
07:45

Assessing Binocular Central Visual Field and Binocular Eye Movements in a Dichoptic Viewing Condition

Published on: July 21, 2020

4.9K
Using Eye-tracking to Assess the Relative Importance of Visual and Vestibular Input to Subcortical Motion Processing in the Roll Plane
07:24

Using Eye-tracking to Assess the Relative Importance of Visual and Vestibular Input to Subcortical Motion Processing in the Roll Plane

Published on: August 22, 2025

415

Area of Science:

  • Neuroscience
  • Ophthalmology
  • Vestibular System

Background:

  • Central vision loss affects visual-vestibular interactions.
  • The preferred retinal locus (PRL) is an area of eccentric vision used to compensate for central scotomas.
  • Understanding how PRL influences reflexes is crucial for vision rehabilitation.

Purpose of the Study:

  • To investigate the horizontal vestibulo-ocular reflex (VOR) in patients with central vision loss and controls.
  • To determine if visual-vestibular interaction (VVOR) during enhanced vision produces gain asymmetry due to PRL location.
  • To test if VOR in darkness is affected by central vision loss.

Main Methods:

  • Examined horizontal VOR and VVOR in 9 patients with central vision loss and 17 controls.
  • Participants performed 10-second active VVOR and VOR at 0.5 Hz in light and darkness.
  • Recorded eye and head movements using a video-based binocular eye tracker; computed gain from peak velocities between saccades.

Main Results:

  • A significant proportion of patients showed leftward VOR asymmetry in both light and darkness.
  • Patient VOR asymmetry was consistent with a PRL located to the left of the scotoma.
  • No VOR asymmetries were observed in control participants.

Conclusions:

  • The preferred retinal locus (PRL) acts as the center of visual direction after central vision loss, even in complete darkness.
  • Visual-vestibular interactions are modulated by the PRL's position in eccentric vision.
  • These findings support the use of PRL-centered strategies in vision rehabilitation for central vision loss.