Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Chronic Pancreatitis II: Collaborative Care01:29

Chronic Pancreatitis II: Collaborative Care

269
The management of chronic pancreatitis is multifaceted, involving a comprehensive approach that includes thorough assessment, diagnostic testing, and a variety of management strategies.
Assessment:
269
Endoscopic Procedures V: ERCP01:26

Endoscopic Procedures V: ERCP

2.4K
Endoscopic Retrograde Cholangiopancreatography (ERCP) is a diagnostic procedure that combines endoscopy and fluoroscopy to diagnose and treat conditions related to the bile ducts, pancreatic ducts, and gallbladder. This procedure is beneficial for identifying and addressing blockages, gallstones, strictures, and tumors within the biliary or pancreatic systems. ERCP is both diagnostic and therapeutic, offering the ability to visualize and treat identified problems in one session.
Patient...
2.4K
Pancreatic Juice and Secretion01:26

Pancreatic Juice and Secretion

2.7K
Pancreatic juice is a clear fluid produced by the pancreas, containing water, salts, sodium bicarbonate, and enzymes vital for digestion in the small intestine. It helps break down large molecules, facilitating nutrient absorption.
When acidic chyme from the stomach enters the duodenum, it triggers the release of secretin, a hormone that prompts pancreatic juice secretion. After a fatty meal, cholecystokinin, another hormone, stimulates gallbladder contraction and enhances enzyme-rich...
2.7K
Chronic Pancreatitis I: Introduction01:24

Chronic Pancreatitis I: Introduction

637
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
637
Acute Pancreatitis I: Introduction01:27

Acute Pancreatitis I: Introduction

1.1K
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
1.1K
Acute Pancreatitis II: Clinical Manifestations and Management01:30

Acute Pancreatitis II: Clinical Manifestations and Management

671
Acute pancreatitis presents a complex medical emergency characterized by rapid onset inflammation of the pancreas, demanding timely diagnosis and management to prevent complications. The condition primarily manifests through severe upper abdominal pain that often radiates to the back. This pain intensifies following the consumption of fatty foods. Accompanying symptoms such as nausea, vomiting, abdominal distention, fever, dyspnea, cyanosis, and jaundice can vary in intensity but significantly...
671

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Staged approach to overcome hyperbilirubinemia: tailored chemotherapy in liver metastases-a case report.

Journal of gastrointestinal oncology·2026
Same author

An overview of KRAS-targeting therapies for colorectal cancer in phase I and II development.

Expert opinion on investigational drugs·2026
Same author

PCNA Inhibition Enhances the Antitumor Activity of KRAS-Targeted Therapies in Pancreatic Cancer.

bioRxiv : the preprint server for biology·2025
Same author

Co-targeting KRAS and Exportin1 as an effective therapeutic strategy for KRASG12D mutant pancreatic ductal adenocarcinoma.

bioRxiv : the preprint server for biology·2025
Same author

An Update on Novel Pharmacotherapies for the Treatment of Neuroendocrine Tumors.

International journal of molecular sciences·2025
Same author

XPO1 inhibition in KRAS-mutant cancers: time for clinical trials but how?

Translational lung cancer research·2025

Related Experiment Video

Updated: Jan 3, 2026

Surface Engineering of Pancreatic Islets with a Heparinized StarPEG Nanocoating
05:35

Surface Engineering of Pancreatic Islets with a Heparinized StarPEG Nanocoating

Published on: June 23, 2018

7.7K

Pancreatic Enzyme Replacement Therapy: A Concise Review.

Gregory T Brennan1, Muhammad Wasif Saif2

  • 1Division of Gastroenterology, University of California Irvine, Orange, California.

JOP : Journal of the Pancreas
|November 19, 2019
PubMed
Summary
This summary is machine-generated.

Pancreatic enzyme replacement therapy (PERT) effectively treats pancreatic exocrine insufficiency. This review offers a clinical guide to PERT dosing and management for conditions like chronic pancreatitis.

Keywords:
ChronicExocrine Pancreatic InsufficiencyPancreatic NeoplasmsPancreatitisSteatorrhea

More Related Videos

Robotic-assisted Lateral Pancreaticojejunostomy for Chronic Pancreatitis
11:07

Robotic-assisted Lateral Pancreaticojejunostomy for Chronic Pancreatitis

Published on: September 5, 2025

750
Human Pancreatic Islet Isolation: Part I: Digestion and Collection of Pancreatic Tissue
11:54

Human Pancreatic Islet Isolation: Part I: Digestion and Collection of Pancreatic Tissue

Published on: May 26, 2009

19.9K

Related Experiment Videos

Last Updated: Jan 3, 2026

Surface Engineering of Pancreatic Islets with a Heparinized StarPEG Nanocoating
05:35

Surface Engineering of Pancreatic Islets with a Heparinized StarPEG Nanocoating

Published on: June 23, 2018

7.7K
Robotic-assisted Lateral Pancreaticojejunostomy for Chronic Pancreatitis
11:07

Robotic-assisted Lateral Pancreaticojejunostomy for Chronic Pancreatitis

Published on: September 5, 2025

750
Human Pancreatic Islet Isolation: Part I: Digestion and Collection of Pancreatic Tissue
11:54

Human Pancreatic Islet Isolation: Part I: Digestion and Collection of Pancreatic Tissue

Published on: May 26, 2009

19.9K

Area of Science:

  • Gastroenterology
  • Digestive Health
  • Enzyme Therapy

Background:

  • Pancreatic exocrine insufficiency (PEI) has diverse causes, including chronic pancreatitis, cystic fibrosis, and pancreatic cancer.
  • Accurate diagnosis of PEI is crucial for effective management.
  • Fecal elastase-1 testing is a valuable diagnostic tool for PEI.

Purpose of the Study:

  • To provide a concise clinical guide for healthcare providers on pancreatic enzyme replacement therapy (PERT).
  • To outline optimal dosing strategies and management principles for PEI.
  • To address challenges and ensure effective PERT utilization.

Main Methods:

  • Review of current clinical guidelines and evidence for PERT.
  • Analysis of diagnostic methods for PEI, focusing on fecal elastase-1.
  • Dose titration and optimization strategies for PERT.

Main Results:

  • Pancreatic enzyme replacement therapy (PERT) is confirmed as safe and effective for PEI.
  • Recommended starting doses: 30-40,000 IU with meals and 15-20,000 IU with snacks.
  • Divided dosing throughout meals and re-evaluation for non-responders are key.

Conclusions:

  • PERT is a cornerstone treatment for PEI, offering significant clinical benefits.
  • Adherence to recommended dosing and individualized adjustments are vital for treatment success.
  • This guide aims to enhance clinical practice in managing PEI with PERT.