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Modeling the Functional Network for Spatial Navigation in the Human Brain
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Age-Related Differences in Functional and Structural Connectivity in the Spatial Navigation Brain Network.

Stephen Ramanoël1, Elizabeth York1,2, Marine Le Petit1,3

  • 1Sorbonne Universités, INSERM, CNRS, Institut de la Vision, Paris, France.

Frontiers in Neural Circuits
|November 19, 2019
PubMed
Summary
This summary is machine-generated.

Aging impacts spatial navigation by altering brain connectivity. Older adults show decreased hippocampal connectivity but increased occipital-parietal connectivity, possibly compensating for navigation changes.

Keywords:
MRIconnectivitydiffusionhealthy agingresting-statespatial navigationvision

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Neuroimaging

Background:

  • Spatial navigation relies on complex cognitive functions and interconnected brain networks.
  • Aging affects brain structures like the hippocampus (HC), leading to cognitive decline and navigation impairments.
  • Age-related changes in the brain's spatial navigation network connectivity are not fully understood.

Purpose of the Study:

  • To investigate age-related differences in functional and structural brain connectivity within the spatial navigation network.
  • To explore how connectivity changes in areas like the hippocampus (HC), parahippocampal place area (PPA), and occipital place area (OPA) relate to aging.

Main Methods:

  • Functional and structural neuroimaging analyses were conducted on 19 young and 22 older adults.
  • Connectivity analyses focused on the PPA, retrosplenial cortex (RSC), occipital place area (OPA), hippocampus (HC), and medial prefrontal cortex (mPFC).
  • Regions of interest were defined using functional localizers and anatomical segmentation.

Main Results:

  • Older adults exhibited decreased functional connectivity between visual areas and the HC compared to younger adults.
  • An increase in functional connectivity between the OPA and PPA was observed in older participants.
  • Age-related differences in white matter integrity were found across the navigation network, excluding the OPA.

Conclusions:

  • Findings suggest age-related alterations in functional and structural connectivity within the spatial navigation network.
  • Increased OPA-PPA connectivity may represent a compensatory mechanism for age-related HC changes, potentially favoring egocentric navigation strategies.
  • These insights contribute to understanding the neural basis of navigation deficits in aging.