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Related Concept Videos

Canonical Wnt Signaling Pathway02:54

Canonical Wnt Signaling Pathway

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The gene encoding the main signaling molecules of the Wnt signaling pathways (the Wnt proteins) was discovered almost four decades ago by Nüsslein-Volhard and Wieschaus. They identified and originally named the gene "wingless" (wg) after a phenotype discovered during their landmark genetic screen in Drosophila for body pattern defects. At around the same time, another researcher named Harold Varmus found that a murine tumor virus activates the mammalian wg homolog, Int-1, which...
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Non-Canonical Wnt Signaling Pathways01:41

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Wnt is a zygotic effect gene that is expressed during very early embryonic development. It regulates various processes in animals starting from early development through the adult stage, such as organogenesis in the embryo and maintenance of neuronal and blood stem cells. Wnt proteins can induce a wide variety of intracellular pathways depending upon the specific abilities of different Wnt ligands to form a complex with shared and cognate receptors in the presence of different co-receptors. The...
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Inflammatory Response I: Vascular and Cellular01:30

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The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
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Role Of Notch Signalling In Intestinal Stem Cell Renewal01:12

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Notch signaling was first discovered in Drosophila melanogaster, where it is involved in cell lineage differentiation. Notch signaling regulates the maintenance and differentiation of intestinal stem cells or ISCs by controlling the expression of atonal homolog 1 or Atoh1. Atoh1 directs cells to differentiate into secretory cells.
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Related Experiment Video

Updated: Jan 3, 2026

Screening Bioactive Nanoparticles in Phagocytic Immune Cells for Inhibitors of Toll-like Receptor Signaling
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Wnt Signaling: Pathogen Incursion and Immune Defense.

Suborno Jati1, Tresa Rani Sarraf1, Debdut Naskar2

  • 1Division of Cancer Biology and Inflammatory Disorder, Indian Institute of Chemical Biology, Kolkata, India.

Frontiers in Immunology
|November 19, 2019
PubMed
Summary

Wnt signaling is vital for immune responses against pathogens, but some microbes exploit it for survival. This review explores the Wnt pathway

Keywords:
Wntactincytoskeletonfrizzledimmunitymacrophagemicrobiotapathogen

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Area of Science:

  • Immunology
  • Cell Biology
  • Microbiology

Background:

  • Wnt signaling pathways regulate crucial cellular processes, including immune system function.
  • These pathways are essential for immune surveillance and host defense against microbial infections.
  • Pathogenic microbes can manipulate Wnt signaling to establish niches within the host.

Purpose of the Study:

  • To review the dynamic interplay between Wnt signaling and pathogens.
  • To focus on the roles of macrophages and actin dynamics in this interaction.
  • To explore how Wnt signaling distinguishes between pathogens and commensal microbiota.

Main Methods:

  • Literature review of current and emerging research on Wnt signaling and host-pathogen interactions.
  • Analysis of studies focusing on macrophage function and cytoskeletal regulation.
  • Examination of the relationship between Wnt signaling and the host microbiome.

Main Results:

  • Wnt signaling is a key battleground between host defense and pathogen exploitation.
  • Macrophages and cytoskeletal dynamics are central to Wnt-mediated immune responses.
  • Wnt signaling may play a role in discriminating between harmful pathogens and beneficial commensals.

Conclusions:

  • Understanding the Wnt signaling "tug-of-war" is crucial for developing new therapeutic strategies.
  • Targeting Wnt pathways could enhance host resistance to infection.
  • Further research is needed to elucidate Wnt signaling's role in host-microbiota interactions and pathogen recognition.